Evidence map›Paper›PMID 32071321›Full record

ArticleScientific reports2020

Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes.

Zhong Chen, Xiaowen Lu, Meghan E McGee-Lawrence, Mitchell A Watsky

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Soluble Epoxide Hydrolase Inhibitors Improve Cornea Alkali Wound Healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Mechanobiology in the eye.npj biological physics and mechanics · 2025
    Review
  6. Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhong ChenDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Xiaowen LuDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Meghan E McGee-LawrenceDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID http://orcid.org/0000-0002-2728-5849
Mitchell A WatskyDepartment of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA. mwatsky@augusta.edu.
Augusta University · US

Funding

Vitamin D Metabolism and Function in the Cornea and Anterior SegmentR01EY021747 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATSKY, MITCHELL A · 2012 to 2020
$3.1M
NEI NIH HHS R01 EY021747
6 · The paper itself

Abstract

The purpose of this study was to determine if transient cell membrane disruptions (TPMDs) in single keratocytes can trigger signaling events in neighboring keratocytes. Stromal cells were cultured from human corneas (HCSC) and mouse corneas (MCSC). TPMDs were produced using a multiphoton microscope in Cal-520-AM loaded cells. TPMD-induced calcium increases (Ca

Indexed as

AnimalsCalciumCell MembraneCells, CulturedConnexin 43CorneaCorneal KeratocytesCorneal StromaFibroblastsHumansMiceSingle-Cell AnalysisStromal CellsCalciumConnexin 43

Identifiers

PMID32071321
PMCPMC7029045
OpenAlexW3006698190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.