Evidence map›Paper›PMID 32071312›Full record

ArticleNature communications2020

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.

Zhigang Liu, Xiaoshuang Dai, Hongbo Zhang, Renjie Shi, Yan Hui, Xin Jin, Wentong Zhang, Luanfeng Wang, Qianxu Wang, Danna Wang and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed, 7 pooled it
34.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 7 syntheses or guidelines pooled it, 512 citations in OpenAlex.

  1. Pooled it
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  14. Diabetes-Associated Cognitive Impairment: Pathophysiology and Emerging Therapies.Annals of clinical and translational neurology · 2026
    Review
  15. Article
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  18. A modifiable driver of dementia: cognitive impairment in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  19. Article
  20. Article

212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 4 countries.

Zhigang Liu *College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China. zhigangliu@nwsuaf.edu.cn.ORCID http://orcid.org/0000-0002-6863-6561
Xiaoshuang Dai *BGI Institute of Applied Agriculture, BGI-Shenzhen, Shenzhen, 518120, China.ORCID http://orcid.org/0000-0001-6563-7756
Hongbo ZhangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Renjie ShiCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Yan HuiBGI Institute of Applied Agriculture, BGI-Shenzhen, Shenzhen, 518120, China.ORCID http://orcid.org/0000-0002-2388-131X
Xin JinBGI Institute of Applied Agriculture, BGI-Shenzhen, Shenzhen, 518120, China.
Wentong ZhangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0001-9680-1045
Luanfeng WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0003-1912-4524
Qianxu WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Danna WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0001-6899-5436
Jia WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Xintong TanCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0003-3326-2341
Bo RenCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0001-8332-3611
Xiaoning LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0002-6794-8600
Tong ZhaoCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0002-2169-6268
Jiamin WangCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Junru PanCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.ORCID http://orcid.org/0000-0002-4316-0851
Tian YuanCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Chuanqi ChuCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China.
Lei LanBGI Institute of Applied Agriculture, BGI-Shenzhen, Shenzhen, 518120, China.
Fei YinCenter for Innovation in Brain Science and Department of Pharmacology, University of Arizona, Tucson, 85721, AZ, USA.ORCID http://orcid.org/0000-0002-5996-2410
Enrique CadenasPharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, 90089, CA, USA.
Lin ShiDivision Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden. shlin@chalmers.se.ORCID http://orcid.org/0000-0001-9709-3394
Shancen ZhaoBGI Institute of Applied Agriculture, BGI-Shenzhen, Shenzhen, 518120, China. zhaoshancen@genomics.cn.
Xuebo LiuCollege of Food Science and Engineering, Northwest A&F University, Yangling, 712100, China. xueboliu@nwsuaf.edu.cn.ORCID http://orcid.org/0000-0001-6370-2868
Northwest A&F University · CNBGI Group (China) · CNNorth West Agriculture and Forestry University · CNChalmers University of Technology · SEUniversity of Arizona · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.

Indexed as

FastingAnimalsBrainCognitionCognitive DysfunctionComputational BiologyDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Energy MetabolismFatty Acids, VolatileGastrointestinal MicrobiomeGene Expression RegulationHippocampusIndolesInsulin ResistanceMale3-(indol-3-yl)propionic acidFatty Acids, VolatileIndolesPropionatesRNA, Ribosomal, 16SSerotoninTaurochenodeoxycholic Acidursodoxicoltaurine

Identifiers

PMID32071312
PMCPMC7029019
OpenAlexW3008031857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.