Evidence map›Paper›PMID 32071275›Full record

ArticlemBio2020

Cryptococcus neoformans Chitin Synthase 3 Plays a Critical Role in Dampening Host Inflammatory Responses.

Camaron R Hole, Woei C Lam, Rajendra Upadhya, Jennifer K Lodge

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. TREM2 drives monocyte-derived macrophage responses tobioRxiv : the preprint server for biology · 2026
    Article
  4. Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. ReportedFEMS microbes · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Lack of an atypical PDR transporter generates an immunogenicbioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024
    Review
  18. Article
  19. Article
  20. Architecture of the dynamic fungal cell wall.Nature reviews. Microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Camaron R HoleDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Woei C LamDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Rajendra UpadhyaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Jennifer K LodgeDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA lodgejk@wustl.edu.
Washington University in St. Louis · US

Funding

Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
Preclinical studies of a Cryptococcus vaccine for AIDS patientsR01AI125045 · NIAID · WASHINGTON UNIVERSITY · PI LEVITZ, STUART MICHAEL, LODGE, JENNIFER K. · 2016 to 2025
$7.1M
Chitosan in CryptococcusR01AI072195 · NIAID · WASHINGTON UNIVERSITY · PI LODGE, JENNIFER K. · 2008 to 2018
$3.5M
NIAID NIH HHS R01 AI072195NIAID NIH HHS R01 AI125045NIAID NIH HHS T32 AI007172
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acquired Immunodeficiency SyndromeAmidohydrolasesAnimalsCARD Signaling Adaptor ProteinsCell WallChemokinesChitinChitin SynthaseChitosanCryptococcosisCryptococcus neoformansCytokinesDisease Models, AnimalInflammationLungMiceAmidohydrolasesCard9 protein, mouseCARD Signaling Adaptor ProteinsChemokinesChitinchitin deacetylaseChitin SynthaseChitosanCytokinesMyd88 protein, mouseMyeloid Differentiation Factor 88chitinchitin synthasechitosaninflammationneutrophils

Identifiers

PMID32071275
PMCPMC7029146
OpenAlexW3007398425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.