Evidence map›Paper›PMID 32071269›Full record

ArticlemBio2020

Respiratory Viral Infection Alters the Gut Microbiota by Inducing Inappetence.

Helen T Groves, Sophie L Higham, Miriam F Moffatt, Michael J Cox, John S Tregoning

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 1 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 1 synthesis or guideline pooled it, 215 citations in OpenAlex.

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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Helen T GrovesMucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St Mary's Campus, Imperial College London, London, United Kingdom.
Sophie L HighamMucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St Mary's Campus, Imperial College London, London, United Kingdom.
Miriam F Moffatt *National Heart & Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0001-7623-5840
Michael J Cox *National Heart & Lung Institute, Imperial College London, London, United Kingdom m.j.cox@bham.ac.uk john.tregoning@imperial.ac.uk.ORCID 0000-0002-4002-1506
John S Tregoning *Mucosal Infection and Immunity Group, Section of Virology, Department of Medicine, St Mary's Campus, Imperial College London, London, United Kingdom m.j.cox@bham.ac.uk john.tregoning@imperial.ac.uk.ORCID 0000-0001-8093-8741
Imperial College London · GBRoyal Brompton & Harefield NHS Foundation Trust · GB

Funding

Medical Research Council MR/K501281/1Wellcome Trust
6 · The paper itself

Abstract

Respiratory viral infections are extremely common, but their impacts on the composition and function of the gut microbiota are poorly understood. We previously observed a significant change in the gut microbiota after viral lung infection. Here, we show that weight loss during respiratory syncytial virus (RSV) or influenza virus infection was due to decreased food consumption, and that the fasting of mice altered gut microbiota composition independently of infection. While the acute phase tumor necrosis factor alpha (TNF-α) response drove early weight loss and inappetence during RSV infection, this was not sufficient to induce changes in the gut microbiota. However, the depletion of CD8

Indexed as

MetabolomeAnimalsAnorexiaAppetiteBacteriaCD8-Positive T-LymphocytesDisease Models, AnimalEatingFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeHumansInfluenza, HumanLipid MetabolismLipidsFatty Acids, VolatileLipidsTumor Necrosis Factor-alphaappetitelung infectionmetabolomemicrobiomerespiratory syncytial virusT cell

Identifiers

PMID32071269
PMCPMC7029140
OpenAlexW3008716294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.