Evidence map›Paper›PMID 32071223›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.

Cameron T McDaniel, Warunya Panmanee, Geoffrey L Winsor, Erin Gill, Claire Bertelli, Michael J Schurr, Prateek Dongare, Andrew T Paul, Seung-Hyun B Ko, Gee W Lau and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 9 institutions in 2 countries.

Cameron T McDanielDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
Warunya PanmaneeDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
Geoffrey L WinsorMolecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0001-6848-1638
Erin GillCentre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Claire BertelliMolecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0003-0550-8981
Michael J SchurrDepartment of Microbiology and Immunology, University of Colorado at Denver, Aurora, CO 80045.
Prateek DongareDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.ORCID 0000-0002-4630-4865
Andrew T PaulDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
Seung-Hyun B KoDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
Gee W LauCollege of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802.ORCID 0000-0002-7962-3950
Nupur DasguptaComputational Medicine Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Amy L BogueDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.
William E MillerDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267.ORCID 0000-0001-6900-4884
Joel E MortensenDiagnostic and Infectious Disease Testing Laboratory, Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
David B HaslamDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Phillip DexheimerComputational Medicine Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Daniel A MuruveDepartment of Medicine, University of Calgary, Calgary, AB T2N4Z6, Canada.
Bruce J AronowComputational Medicine Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.
Malcolm D E ForbesCenter for Photochemical Studies, Bowling Green State University, Bowling Green, OH 43403.
Marek DanilczukCenter for Photochemical Studies, Bowling Green State University, Bowling Green, OH 43403.
Fiona S L BrinkmanMolecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
Robert E W HancockCentre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Thomas J MeyerDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; tjmeyer@unc.edu daniel.hassett@uc.edu.ORCID 0000-0002-7006-2608
Daniel J HassettDepartment of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267; tjmeyer@unc.edu daniel.hassett@uc.edu.
University of Cincinnati Medical Center · USCincinnati Children's Hospital Medical Center · USSimon Fraser University · CABowling Green State University · USUniversity of British Columbia · CAUniversity of North Carolina at Chapel Hill · USUniversity of Calgary · CAUniversity of Colorado Denver · USUniversity of Illinois Urbana-Champaign · US

Funding

The LungMAP Data Coordination Center for Next Gen Systems Biology of RespirationU24HL148865 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Bruce J Aronow, Nathan G. Salomonis · 2019 to 2026
$12.4M
NHLBI NIH HHS U24 HL148865
6 · The paper itself

Abstract

Antibiotic-resistant superbug bacteria represent a global health problem with no imminent solutions. Here we demonstrate that the combination (termed AB569) of acidified nitrite (A-NO

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaBiofilmsDisease Models, AnimalDown-RegulationDrug Resistance, BacterialEdetic AcidLung DiseasesMetabolic Networks and PathwaysMiceNitritesPseudomonas aeruginosaSodium NitriteAnti-Bacterial AgentsEdetic AcidNitritesSodium Nitriteantibiotic resistancebactericidalbiofilmEDTAsodium nitrite

Identifiers

PMID32071223
PMCPMC7060718
OpenAlexW3007425510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.