ArticleProceedings of the National Academy of Sciences of the United States of America2020
Evidence that Criegee intermediates drive autoxidation in unsaturated lipids.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 67 citations in OpenAlex.
- Radical-induced autoxidation dominates squalene oxidative aging under environmental conditions.Science advances · 2026Article
- Hydroxyl radical as an indoor oxidant.Environmental science: atmospheres · 2026Review
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Mechanistic Insights into Novel Water-Mediated Sustainable Synthesis of Dicarboxylic Acids in Green Solvent Systems.ACS omega · 2026Article
- Fast autoxidation of unsaturated lipid films on indoor surfaces.Nature communications · 2025Article
- Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects.Environment & health (Washington, D.C.) · 2025Review
- Nanocluster Aerosols from Ozone-Human Chemistry Are Dominated by Squalene-Ozone Reactions.Environmental science & technology letters · 2024Article
- Influence of Ventilation on Formation and Growth of 1-20 nm Particles via Ozone-Human Chemistry.Environmental science & technology · 2024Article
- A radical polymer membrane for simultaneous degradation of organic pollutants and water filtration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dynamic changes to the plant cuticle include the production of volatile cuticular wax-derived compounds.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Elucidating the photodissociation fingerprint and quantifying the determination of organic hydroperoxides in gas-phase autoxidation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Synthesis of Sterically Encumbered Thiourea S-Oxides through Direct Thiourea Oxidation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Stability of Terpenoid-Derived Secondary Ozonides in Aqueous Organic Media.The journal of physical chemistry. A · 2022Article
- Criegee Intermediates Beyond Ozonolysis: Synthetic and Mechanistic Insights.Angewandte Chemie (International ed. in English) · 2021Review
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoxidation is an autocatalytic free-radical chain reaction responsible for the oxidative destruction of organic molecules in biological cells, foods, plastics, petrochemicals, fuels, and the environment. In cellular membranes, lipid autoxidation (peroxidation) is linked with oxidative stress, age-related diseases, and cancers. The established mechanism of autoxidation proceeds via H-atom abstraction through a cyclic network of peroxy-hydroperoxide-mediated free-radical chain reactions. For a series of model unsaturated lipids, we present evidence for an autoxidation mechanism, initiated by hydroxyl radical (OH) addition to C=C bonds and propagated by chain reactions involving Criegee intermediates (CIs). This mechanism leads to unexpectedly rapid autoxidation even in the presence of water, implying that as reactive intermediates, CI could play a much more prominent role in chemistries beyond the atmosphere.
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