Evidence map›Paper›PMID 32071197›Full record

ArticleBMJ open diabetes research & care2020

Adequate 25-hydroxyvitamin D levels are inversely associated with various cardiometabolic risk factors in Chinese children, especially obese children.

Pei Xiao, Hongbo Dong, Haibo Li, Yinkun Yan, Hong Cheng, Junting Liu, Xiaoyuan Zhao, Dongqing Hou, Jie Mi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pei Xiao *Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Hongbo Dong *Department of Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Haibo LiDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Yinkun YanDepartment of Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Hong ChengDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Junting LiuDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Xiaoyuan ZhaoDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Dongqing HouDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, China.
Jie MiDepartment of Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China jiemi12@vip.sina.com.ORCID 0000-0003-0630-8447
Capital Institute of Pediatrics · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVitamin D deficiency has recently evolved as a major public health issue worldwide. But the relationship between vitamin D and cardiovascular health in children remains unclear. Accordingly, we aimed to examine the associations between 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors, and to assess the possible effect modification of obesity on the associations in a Chinese pediatric population. RESEARCH DESIGN AND

methodsA cross-sectional sample of 6091 children aged 6-18 years was obtained using a cluster sampling method. The 25(OH)D concentrations, and metabolic risk factors, including waist to height ratio, blood pressure, blood lipids, fasting blood glucose (FBG), and insulin were measured. Adjusted ORs and multiplicative or additive interaction were calculated to assess the associations and effect modification, respectively.

resultsTriglycerides, FBG, insulin, and homeostasis model assessment of insulin resistance were inversely associated with 25(OH)D concentrations (p<0.05) in both sexes. The OR of hyperglycemia among individuals with insufficient vitamin D was higher than those with adequate vitamin D after adjusting for covariates (OR: 1.47; 95% CI 1.26 to 1.70). Moreover, girls with insufficient vitamin D had significantly higher odds for hypertension and high total cholesterol than those with adequate vitamin D, which was not observed in boys. Thirty-two percent (95% CI 14% to 51%) of the increased odds of hyperglycemia can be explained by the interaction between insufficient vitamin D and obesity.

conclusionsVitamin D insufficiency is associated with increased odds of various cardiometabolic risk factors in Chinese children and has a synergistic effect on hyperglycemia with obesity.

Indexed as

Cardiometabolic Risk FactorsAdolescentBlood GlucoseCardiovascular DiseasesChildChinaCross-Sectional StudiesFemaleHumansHyperglycemiaMalePediatric ObesityPrevalenceTriglyceridesVitamin DVitamin D Deficiency25-hydroxyvitamin DBlood GlucoseTriglyceridesVitamin Dcardiovascular disease riskchildrenhyperglycemiapopulation-based interaction

Identifiers

PMID32071197
PMCPMC7039595
OpenAlexW3005678802

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.