ArticleGenetics2020
The Temporal Dynamics of Background Selection in Nonequilibrium Populations.
Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Evolution of quantitative traits with background selection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity.bioRxiv : the preprint server for biology · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Accessible, Realistic Genome Simulation with Selection Using stdpopsim.Molecular biology and evolution · 2025Article
- A model for background selection in non-equilibrium populations.bioRxiv : the preprint server for biology · 2025Article
- Accessible, realistic genome simulation with selection using stdpopsim.bioRxiv : the preprint server for biology · 2025Article
- Evolution of Functional Genomic Diversity During a Bottleneck.Genome biology and evolution · 2025Article
- Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations.Genetics · 2025Article
- Detection of domestication signals through the analysis of the full distribution of fitness effects.Peer community journal · 2025Article
- Population size rescaling significantly biases outcomes of forward-in-time population genetic simulations.bioRxiv : the preprint server for biology · 2024Article
- An efficient and robust ABC approach to infer the rate and strength of adaptation.G3 (Bethesda, Md.) · 2024Article
- Background Selection From Unlinked Sites Causes Nonindependent Evolution of Deleterious Mutations.Genome biology and evolution · 2024Article
- A quantitative genetic model of background selection in humans.PLoS genetics · 2024Article
- Recurrent mutation in the ancestry of a rare variant.Genetics · 2023Article
- Article
- Background selection under evolving recombination rates.Proceedings. Biological sciences · 2022Article
- A Nearly Neutral Model of Molecular Signatures of Natural Selection after Change in Population Size.Genome biology and evolution · 2022Article
- Meiotic, genomic and evolutionary properties of crossover distribution in Drosophila yakuba.PLoS genetics · 2022Article
- Bottleneck-associated changes in the genomic landscape of genetic diversity in wild lynx populations.Evolutionary applications · 2021Article
- Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome.PLoS genetics · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
Neutral genetic diversity across the genome is determined by the complex interplay of mutation, demographic history, and natural selection. While the direct action of natural selection is limited to functional loci across the genome, its impact can have effects on nearby neutral loci due to genetic linkage. These effects of selection at linked sites, referred to as genetic hitchhiking and background selection (BGS), are pervasive across natural populations. However, only recently has there been a focus on the joint consequences of demography and selection at linked sites, and some empirical studies have come to apparently contradictory conclusions as to their combined effects. To understand the relationship between demography and selection at linked sites, we conducted an extensive forward simulation study of BGS under a range of demographic models. We found that the relative levels of diversity in BGS and neutral regions vary over time and that the initial dynamics after a population size change are often in the opposite direction of the long-term expected trajectory. Our detailed observations of the temporal dynamics of neutral diversity in the context of selection at linked sites in nonequilibrium populations provide new intuition about why patterns of diversity under BGS vary through time in natural populations and help reconcile previously contradictory observations. Most notably, our results highlight that classical models of BGS are poorly suited for predicting diversity in nonequilibrium populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.