ArticleScience signaling2020
Fluoride exposure alters Ca
Article in Science signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Fluoride as a Modifier of Metallome Homeostasis: A Systematic Review of Animal Studies.Basic & clinical pharmacology & toxicology · 2026Pooled it
- Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial.Scientific reports · 2021Trial
- Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome.Cell reports · 2026Article
- Effects of fluoride and lead on enamel composition during the maturation stage of amelogenesis in rat mandibular third molars.Calcified tissue international · 2026Review
- Dental fluorosis in the European roe deer (Capreolus capreolus): A review of the pathological changes in the enamel of fluorotic cheek teeth and the abnormal pattern of dental wear in affected dentitions.Anatomical record (Hoboken, N.J. : 2007) · 2026Review
- Hybrid dansyl-triazine based mono and bidentate ligands for the selective sensing of fluoride anion through fluorescence enhancement.RSC advances · 2025Article
- Histological effect of fluoride varnishes on teeth with caries in the white spot phase: AnJournal of clinical and experimental dentistry · 2025Article
- Roles of calcium in ameloblasts during tooth development: A scoping review.Journal of Taibah University Medical Sciences · 2025Review
- From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration.Stem cell reviews and reports · 2024Review
- Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger.The Journal of general physiology · 2024Article
- The CaScience signaling · 2023Article
- Fluoride as a Potential Repressor of Glycogen Metabolism in Skeletal Muscle Cell Line CCL136.Molecules (Basel, Switzerland) · 2023Article
- The Application of a Fluoride-and-Vitamin D Solution to Deciduous Teeth Promotes Formation of Persistent Mineral Crystals: A Morphological Ex-Vivo Study.Materials (Basel, Switzerland) · 2023Article
- Fluoride in the Central Nervous System and Its Potential Influence on the Development and Invasiveness of Brain Tumours-A Research Hypothesis.International journal of molecular sciences · 2023Review
- Advances in epidemiological status and pathogenesis of dental fluorosis.Frontiers in cell and developmental biology · 2023Review
- Saliva microbiome alterations in dental fluorosis population.Journal of oral microbiology · 2023Article
- Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study.Journal of functional biomaterials · 2022Article
- Overexpression ofCells · 2022Article
- Mitochondria modulate ameloblast CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism.Frontiers in veterinary science · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Fluoride ions are highly reactive, and their incorporation in forming dental enamel at low concentrations promotes mineralization. In contrast, excessive fluoride intake causes dental fluorosis, visually recognizable enamel defects that can increase the risk of caries. To investigate the molecular bases of dental fluorosis, we analyzed the effects of fluoride exposure in enamel cells to assess its impact on Ca
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.