ArticleNeurology2020
ALS is a multistep process in South Korean, Japanese, and Australian patients.
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Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 2 of them syntheses that pooled it.
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39citing papers in PubMed, 2 pooled it
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Analysis of aneurysmal subarachnoid hemorrhage as a multistep process.European journal of neurology · 2024Pooled it
- The contribution of brain banks to knowledge discovery in amyotrophic lateral sclerosis: A systematic review.Neuropathology and applied neurobiology · 2022Pooled it
- Safety and efficacy of dimethyl fumarate in ALS: randomised controlled study.Annals of clinical and translational neurology · 2021Trial
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Exploring the ALS Multistep Model.Brain sciences · 2026Review
- Multimorbidity as a multistage disease process.PNAS nexus · 2026Article
- The multistep pathogenic hypothesis of amyotrophic lateral sclerosis is incompatible with the epidemiological data.European journal of epidemiology · 2026Article
- Entering the era of precision medicine to treat amyotrophic lateral sclerosis.Molecular neurodegeneration · 2025Review
- Hospital-treated infections and the risk and prognosis of amyotrophic lateral sclerosis: A population-based study.Journal of internal medicine · 2025Article
- Pan-Asian consortium for treatment and research in ALS (PACTALS) guidelines for management of amyotrophic lateral sclerosis.The Lancet regional health. Western Pacific · 2025Review
- Amyotrophic Lateral Sclerosis as a Multistep Process in the United States: A Population-Based Study.Annals of clinical and translational neurology · 2025Article
- A population based study to analyse amyotrophic lateral sclerosis as a multi-step process.Scientific reports · 2025Article
- Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse.BMC medicine · 2025Article
- The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations.Brain sciences · 2025Review
- ATXN2 polyglutamine intermediate repeats length expansions in Malaysian patients with amyotrophic lateral sclerosis (ALS).Neurogenetics · 2025Article
- Implications of perivascular spaces in amyotrophic lateral sclerosis: clinical significance and structural correlation.Brain communications · 2025Article
- Twitch force in human Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2025Article
- Amyotrophic lateral sclerosis established as a multistep process across phenotypes.European journal of neurology · 2025Article
- Article
- Physiological Biomarkers of Upper Motor Neuron Dysfunction in ALS.Brain sciences · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Steve VucicFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia. steve.vucic@sydney.edu.au.
Mana HigashiharaFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Gen SobueFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Naoki AtsutaFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Yuriko DoiFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Satoshi KuwabaraFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Seung Hyun KimFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Inah KimFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Ki-Wook OhFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Jinseok ParkFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Eun Mi KimFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.ORCID 0000-0003-4290-5441
Paul TalmanFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Parvathi MenonFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
Matthew C KiernanFrom the Westmead Clinical School (S.V., M.H., P.M.), University of Sydney, Australia; Department of Neurology (N.A.), Nagoya University Graduate School of Medicine (G.S.); The National Institute of Public Health (Y.D.), Wako-shi; Chiba University Graduate School of Medicine (S.K.), Japan; Department of Neurology (S.H.K., K.-W.O., J.P.), Hanyang University Hospital; Department of Health Sciences (I.K., E.M.K.), Hanyang University Graduate School; Department of Occupational and Environmental Medicine (I.K.), College of Medicine, Hanyang University, Seoul, Republic of Korea; Geelong Hospital (P.T.); and Brain and Mind Centre (M.C.K.), University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.
PACTALS Consortium
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo establish whether amyotrophic lateral sclerosis (ALS) is a multistep process in South Korean and Japanese populations when compared to Australian cohorts.
methodsWe generated incident data by age and sex for Japanese (collected between April 2009 and March 2010) and South Korean patients with ALS (collected between January 2011 and December 2015). Mortality rates were provided for Australian patients with ALS (collected between 2007 and 2016). We regressed the log of age-specific incidence against the log of age with least squares regression for each ALS population.
resultsWe identified 11,834 cases of ALS from the 3 populations, including 6,524 Australian, 2,264 Japanese, and 3,049 South Korean ALS cases. We established a linear relation between the log incidence and log age in the 3 populations: Australia
conclusionsThe linear relationship between log age and log incidence is consistent with a multistage model of disease, with slope estimated suggesting that 6 steps were required in Japanese and Australian patients with ALS while 5 steps were needed in South Korean patients. Identification of these steps could identify novel therapeutic strategies.
Indexed as
Disease ProgressionAdultAgedAmyotrophic Lateral SclerosisAustraliaFemaleHumansIncidenceJapanMaleMiddle AgedRacial GroupsRepublic of Korea
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