ArticleCancer prevention research (Philadelphia, Pa.)2020
External Validation of Risk Prediction Models Incorporating Common Genetic Variants for Incident Colorectal Cancer Using UK Biobank.
Article in Cancer prevention research (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank.British journal of cancer · 2026Pooled it
- Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Guideline
- MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle.medRxiv : the preprint server for health sciences · 2026Article
- Identification and management of genetic susceptibility to cancer: UK perspective.BMJ oncology · 2026Review
- Cancer incidence inconsistency between UK Biobank participants and the population: a prospective cohort study.BMC medicine · 2025Article
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- Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data.Cancer biology & medicine · 2024Article
- How Genome-Wide Association Studies Transform Care for Patients at Risk of Glaucoma.Expert review of ophthalmology · 2024Article
- Colorectal Cancer Polygenic Risk Score Is Associated With Screening Colonoscopy Findings but Not Follow-Up Outcomes.Gastro hep advances · 2024Article
- Assessments of dietary intake and polygenic risk score in associations with colorectal cancer risk: evidence from the UK Biobank.BMC cancer · 2023Article
- A single measurement of fecal hemoglobin concentration outperforms polygenic risk score in colorectal cancer risk assessment.Cancer communications (London, England) · 2023Article
- Validation of a Genetic-Enhanced Risk Prediction Model for Colorectal Cancer in a Large Community-Based Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence.BMC medical genomics · 2023Article
- Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study.BMJ (Clinical research ed.) · 2022Article
- The current state of genetic risk models for the development of kidney cancer: a review and validation.BJU international · 2022Review
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- External validation of models for predicting risk of colorectal cancer using the China Kadoorie Biobank.BMC medicine · 2022Article
- Risk-stratified strategies in population screening for colorectal cancer.International journal of cancer · 2022Review
- Future of Colorectal Cancer Screening: From One-Size-FITs-All to Tailor-Made.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 4 countries.
Funding
Abstract
The aim of this study was to compare and externally validate risk scores developed to predict incident colorectal cancer that include common genetic variants (SNPs), with or without established lifestyle/environmental (questionnaire-based/classical/phenotypic) risk factors. We externally validated 23 risk models from a previous systematic review in 443,888 participants ages 37 to 73 from the UK Biobank cohort who had 6-year prospective follow-up, no prior history of colorectal cancer, and data for incidence of colorectal cancer through linkage to national cancer registries. There were 2,679 (0.6%) cases of incident colorectal cancer. We assessed model discrimination using the area under the operating characteristic curve (AUC) and relative risk calibration. The AUC of models including only SNPs increased with the number of included SNPs and was similar in men and women: the model by Huyghe with 120 SNPs had the highest AUC of 0.62 [95% confidence interval (CI), 0.59-0.64] in women and 0.64 (95% CI, 0.61-0.66) in men. Adding phenotypic risk factors without age improved discrimination in men but not in women. Adding phenotypic risk factors and age increased discrimination in all cases (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.