Evidence map›Paper›PMID 32071061›Full record

ArticleAntimicrobial agents and chemotherapy2020

Discordance between Etravirine Phenotype and Genotype-Based Predicted Phenotype for Subtype C HIV-1 from First-Line Antiretroviral Therapy Failures in South Africa.

Kevin D McCormick, Kerri J Penrose, Chanson J Brumme, P Richard Harrigan, Raquel V Viana, John W Mellors, Urvi M Parikh, Carole L Wallis

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Kevin D McCormickUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA kdm32@pitt.edu.
Kerri J PenroseUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chanson J BrummeBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
P Richard HarriganFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Raquel V VianaBARC-SA and Lancet Laboratories, Johannesburg, South Africa.
John W MellorsUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Urvi M ParikhUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Carole L WallisBARC-SA and Lancet Laboratories, Johannesburg, South Africa.
University of Pittsburgh · USLancet Laboratories · ZAUniversity of British Columbia · CA

Funding

CIHRPEPFAR
6 · The paper itself

Abstract

Etravirine (ETR) is a nonnucleoside reverse transcriptase inhibitor (NNRTI) used in treatment-experienced individuals. Genotypic resistance test-interpretation systems can predict ETR resistance; however, genotype-based algorithms are derived primarily from HIV-1 subtype B and may not accurately predict resistance in non-B subtypes. The frequency of ETR resistance among recombinant subtype C HIV-1 and the accuracy of genotypic interpretation systems were investigated. HIV-1

Indexed as

AlgorithmsAnti-Retroviral AgentsDrug Resistance, ViralGenotypeHIV-1HIV InfectionsHumansMicrobial Sensitivity TestsNitrilesPyrimidinesReverse Transcriptase InhibitorsSouth AfricaTreatment FailureAnti-Retroviral AgentsetravirineNitrilesPyrimidinesReverse Transcriptase InhibitorsETRetravirinegenotypingHIVdbNNRTIphenotypingsubtype Cthird line

Identifiers

PMID32071061
PMCPMC7179637
OpenAlexW3008969995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.