Evidence map›Paper›PMID 32071049›Full record

ArticleAntimicrobial agents and chemotherapy2020

Evaluation of Dose-Fractionated Polymyxin B on Acute Kidney Injury Using a Translational

Jiajun Liu, Gwendolyn M Pais, Sean N Avedissian, Annette Gilchrist, Andrew Lee, Nathaniel J Rhodes, Alan R Hauser, Marc H Scheetz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiajun LiuMidwestern University, Downers Grove, Illinois, USA.ORCID 0000-0002-4330-2098
Gwendolyn M PaisMidwestern University, Downers Grove, Illinois, USA.ORCID 0000-0003-4961-0048
Sean N AvedissianAntiviral Pharmacology Laboratory, University of Nebraska Medical Center (UNMC), Center for Drug Discovery, Omaha, Nebraska, USA.ORCID 0000-0002-0935-6455
Annette GilchristMidwestern University, Downers Grove, Illinois, USA.ORCID 0000-0003-2386-7646
Andrew LeeDepartment of Chemical & Biological Engineering, Northwestern University, Evanston, Illinois, USA.
Nathaniel J RhodesMidwestern University, Downers Grove, Illinois, USA.ORCID 0000-0002-0018-5434
Alan R HauserNorthwestern University, Chicago, Illinois, USA.
Marc H ScheetzMidwestern University, Downers Grove, Illinois, USA mschee@midwestern.edu.ORCID 0000-0002-1091-6130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated dose-fractionated polymyxin B (PB) on acute kidney injury (AKI). PB at 12 mg of drug/kg of body weight per day (once, twice, and thrice daily) was administered in rats over 72 h. The thrice-daily group demonstrated the highest KIM-1 increase (

Indexed as

Acute Kidney InjuryAnimalsAnti-Bacterial AgentsArea Under CurveCell Adhesion MoleculesDisease Models, AnimalDose-Response Relationship, DrugKidney Function TestsMalePolymyxin BRatsRats, Sprague-DawleyTranslational Research, BiomedicalAnti-Bacterial AgentsCell Adhesion MoleculesHavcr1 protein, ratPolymyxin Bacute kidney injuryanimal modelcolistinpharmacodynamicpharmacokineticpolymyxin Bpolymyxinstoxicodynamicurinary biomarker

Identifiers

PMID32071049
PMCPMC7179599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.