ArticleAntimicrobial agents and chemotherapy2020
Novel Insights into the Classification of Staphylococcal β-Lactamases in Relation to the Cefazolin Inoculum Effect.
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In one paragraph
Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2026Review
- The inoculum effect of methicillin-susceptibleMicrobiology spectrum · 2026Article
- Cefazolin Inoculum Effect and Cefazolin Microbiological Treatment Failure in Serious Methicillin-Susceptible Staphylococcus aureus Infections: A Multicenter Retrospective Cohort Study.The Journal of infectious diseases · 2026Article
- The Cefazolin Inoculum Effect: An Underappreciated Factor in MSSA Treatment Strategies.Infectious diseases and therapy · 2026Review
- Staphylococcus aureus genotypic penicillin susceptibility using a blaZ qPCR directly on blood cultures shows high concordance with phenotype.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Optimizing cefazolin dosing for central nervous system infections: insights from population pharmacokinetics and Monte Carlo simulations.Antimicrobial agents and chemotherapy · 2025Article
- Validation of a modified rapid test to detect the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus from bloodstream infections in hospitals from North and Latin America.The Journal of antimicrobial chemotherapy · 2025Article
- Discordant β-Lactam Susceptibility in ClinicalMicroorganisms · 2024Article
- Prevalence of the cefazolin inoculum effect (CzIE) in nasal colonizing methicillin-susceptibleAntimicrobial agents and chemotherapy · 2024Article
- Prevalence of the Cefazolin Inoculum Effect (CzIE) in Nasal Colonizing Methicillin-SusceptiblemedRxiv : the preprint server for health sciences · 2024Article
- Clinical significance of cefazolin inoculum effect in serious MSSA infections: a systematic review.JAC-antimicrobial resistance · 2024Review
- Epidemiology and impact of methicillin-sensitiveAntimicrobial agents and chemotherapy · 2023Article
- Disc Test for Detecting Staphylococcus aureus Strains Producing Type A and Type C β-Lactamases.Microbiology spectrum · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Observational
- Genomic epidemiology and characterisation of penicillin-sensitiveEmerging microbes & infections · 2022Article
- Molecular Epidemiology of Penicillin-SusceptibleMicroorganisms · 2022Article
- Prevalence and Characterization of the Cefazolin Inoculum Effect in North American Methicillin-Susceptible Staphylococcus aureus Isolates.Journal of clinical microbiology · 2022Article
- Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients.Open forum infectious diseases · 2022Article
- A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.Journal of clinical microbiology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Lina P CarvajalMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Sandra RinconMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Aura M EcheverriMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Jessica PorrasMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Rafael RiosMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Karen M OrdoñezE.S.E. Hospital Universitario San Jorge de Pereira, Risaralda, Colombia.
Carlos SeasHospital Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.
Sara I Gomez-VillegasCenter for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Lorena DiazMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia.
Cesar A AriasCenter for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Jinnethe ReyesMolecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia reyesjinnethe@unbosque.edu.co.
Universidad El Bosque · COThe University of Texas Health Science Center at Houston · USESE University Hospital San Jorge Pereira · COUniversidad Peruana Cayetano Heredia · PE
Funding
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7MPOR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5MMolecular basis of the cefazolin inoculum effectR21AI143229 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2019 to 2020
$442kNIAID NIH HHS K24 AI121296NIAID NIH HHS R01 AI134637NIAID NIH HHS R21 AI143229
Abstract
Cefazolin has become a prominent therapy for methicillin-susceptible
Indexed as
Anti-Bacterial AgentsBacteremiabeta-LactamasesCefazolinDrug Resistance, BacterialHumansLatin AmericaMicrobial Sensitivity TestsMolecular EpidemiologyPhylogenyPrevalenceStaphylococcal InfectionsStaphylococcus aureusWhole Genome SequencingAnti-Bacterial Agentsbeta-lactamase CMY-2beta-LactamasesCefazolinBlaZ allotypescefazolininoculum effectMSSA
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.