Evidence map›Paper›PMID 32070924›Full record

ReviewCell calcium2020

Modulation of the cardiac Na

Kyle Scranton, Scott John, Ariel Escobar, Joshua I Goldhaber, Michela Ottolia

Open access · greenAbstract readReview
In one paragraph

Review in Cell calcium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. CaBiomolecules · 2025
    Review
  2. Regulation of Na/Ca exchange by cytoplasmic protons modifies intracellular calcium dynamics and the cardiac response to ischemia.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Structural dynamics of NaCommunications biology · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kyle ScrantonDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, UCLA, Los Angeles, CA 90095, USA.
Scott JohnDepartment of Medicine (Cardiology), UCLA, Los Angeles, CA 90095, USA; Cardiovascular Research Laboratory, UCLA, Los Angeles, CA 90095, USA.
Ariel EscobarDepartment of Bioengineering, School of Engineering, UC Merced, Merced, CA 95343, USA.
Joshua I GoldhaberSmidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Michela OttoliaDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, UCLA, Los Angeles, CA 90095, USA; Cardiovascular Research Laboratory, UCLA, Los Angeles, CA 90095, USA. Electronic address: mottolia@ucla.edu.
University of California, Los Angeles · USCedars-Sinai Medical Center · USUniversity of California, Merced · US

Funding

Regulation of cellular calcium by cardiac sodium-calcium exchangeR01HL147569 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GOLDHABER, JOSHUA I, OTTOLIA, MICHELA · 2019 to 2022
$2.6M
The Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulationR01HL130308 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OTTOLIA, MICHELA · 2016 to 2019
$1.6M
NHLBI NIH HHS R01 HL130308NHLBI NIH HHS R01 HL147569
6 · The paper itself

Abstract

A precise temporal and spatial control of intracellular Ca

Indexed as

ProtonsAllosteric RegulationAnimalsCytoplasmHumansHydrogen-Ion ConcentrationMyocardiumSodium-Calcium ExchangerProtonsSodium-Calcium ExchangerCa(2+) dynamicsCalcium binding domainsExcitation-contraction couplingNa(+)-Ca(2+) exchangerpH regulationProtons

Identifiers

PMID32070924
PMCPMC7153995
OpenAlexW2995243327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.