ArticleBJPsych open2020
Discontinuing psychotropic drug treatment.
Article in BJPsych open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Perioperative sleep management in cardiac surgery: an evidence-oriented narrative review of pharmacological, behavioral, and respiratory support strategies.Frontiers in cardiovascular medicine · 2026Review
- The role of pharmacogenomics in the discontinuation of psychotropic medication: a scoping review protocol.HRB open research · 2026Article
- Helping people to discontinue antipsychotics: if, when and how.Schizophrenia (Heidelberg, Germany) · 2025Review
- Deprescribing psychoactive drugs in older orthogeriatric patients: findings from the GIOG2.0 Italian survey.BMC geriatrics · 2025Observational
- [Can antidepressants negatively alter the long-term course of depressive disorders?]Der Nervenarzt · 2025Review
- History of Suicide Prevention with Lithium Treatment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Meeting the mental health needs of women in Irish prisons: A qualitative multi-stakeholder perspective to inform healthcare practice.PloS one · 2025Article
- Later is not necessarily better: limitations of survival analysis in studies of long-term drug treatment of psychiatric conditions.BMJ evidence-based medicine · 2022Article
- A systematic search and critical review of studies evaluating psychometric properties of patient-reported outcome measures for schizophrenia.Journal of psychiatric research · 2022Review
- Effects of medical service fee revision on reducing irrational psychotropic polypharmacy in Japan: an interrupted time-series analysis.Social psychiatry and psychiatric epidemiology · 2022Article
- Factors affecting hallucinations in patients with delirium.Scientific reports · 2021Article
- Hamlet's augury: how to manage discontinuation of mood stabilizers in bipolar disorder.Therapeutic advances in psychopharmacology · 2021Review
- Outcome of antidepressant drug discontinuation with taperingstrips after 1-5 years.Therapeutic advances in psychopharmacology · 2020Article
- How effective are antidepressants for depression over the long term? A critical review of relapse prevention trials and the issue of withdrawal confounding.Therapeutic advances in psychopharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interruption of ongoing treatment with benzodiazepines, antidepressants, antipsychotics and mood stabilisers including lithium can be followed by clinically significant withdrawal reactions within hours or days, as well as later increases in relapses or recurrences of the illness being treated. Such observations support the view that stopping treatment is not equivalent to being untreated. With lithium, antipsychotics and antidepressants, there is consistent evidence that abrupt or rapid discontinuation is followed by earlier clinical worsening than with more gradual removal of treatment. Moreover, treatment discontinuation can complicate interpretation of responses to changes in treatment, including in clinical practice and in experimental treatment trials. Notably, terminating preceding treatments can lead to both discontinuation and carry-over effects that can have an impact on the interpretation of observed outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.