ArticleBMC pulmonary medicine2020
Does a pulmonary rehabilitation based ERAS program (PREP) affect pulmonary complication incidence, pulmonary function and quality of life after lung cancer surgery? Study protocol for a multicenter randomized controlled trial.
Article in BMC pulmonary medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Critical analysis of quality of life and cost-effectiveness of enhanced recovery after surgery (ERAS) for patient's undergoing urologic oncology surgery: a systematic review.World journal of urology · 2022Pooled it
- Exercise and lung cancer surgery: A systematic review of randomized-controlled trials.Critical reviews in oncology/hematology · 2020Pooled it
- A visualization analysis of research hotspots and trends in enhanced recovery after surgery (ERAS) for elderly patients based on web of science and scopus.Journal of cardiothoracic surgery · 2026Article
- Impact of nonintubated versus intubated anesthesia on postoperative pulmonary complications after video-assisted thoracoscopic lung resection: A retrospective cohort study.The Journal of international medical research · 2026Article
- Effect of preoperative inspiratory muscle training combined with education course on postoperative pulmonary complications in high-risk patients with lung cancer after video-assisted thoracoscopic surgery: a randomized controlled trial.Contemporary clinical trials communications · 2026Article
- A Qualitative Study on the Psychological Experience of Lung Cancer Patients During the Perioperative Period.Cancer management and research · 2026Article
- The Effects of Surface Gastrointestinal Electrical Stimulation on Gastrointestinal Function Recovery in Patients After Acute Type A Aortic Dissection Open-Heart Surgery: A Randomized, Controlled Trial.Reviews in cardiovascular medicine · 2025Article
- Video- assisted thoracoscopic lung resection with or without enhanced recovery after surgery: a single institution, prospective randomized controlled study.Frontiers in oncology · 2024Article
- Use of the speed achieved on the 6MWT for programming aerobic training in patients recovering from severe COVID-19: an observational study.Annals of medicine · 2023Observational
- An Accessible Pre-Rehabilitation Bundle for Patients Undergoing Elective Heart Valve Surgery with Limited Resources: The TIME Randomized Clinical Trial.Reviews in cardiovascular medicine · 2023Article
- The effects of different surgical approaches on the psychological status, medical coping mode and quality of life of patients with lung cancer.Frontiers in psychology · 2023Article
- Recent advances in postoperative pulmonary rehabilitation of patients with non‑small cell lung cancer (Review).International journal of oncology · 2022Review
- Outcomes of enhanced recovery after surgery in lung cancer: A systematic review and meta-analysis.Asia-Pacific journal of oncology nursing · 2022Review
- Effects of Osimertinib Combined With Pulmonary Rehabilitation and Health Care Training on Pulmonary Function, Complications, and Quality of Life in Patients After Radical Resection of Lung Cancer.Frontiers in public health · 2022Article
- Effect of ultrasound-guided pulsed radiofrequency on intercostal neuralgia after lung cancer surgery: A retrospective study.Medicine · 2021Observational
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung cancer surgery is associated with a high incidence of postoperative pulmonary complications (PPCs). Preliminary evidence suggests that ERAS processes can reduce overall incidence of PPCs as short- and long-term recovery improved by supporting units to adopt evidence-based care. However, the evidence is inconclusive due to insufficient high-level studies in this research field. No well-designed, adequately powered, randomized controlled trials (RCTs) have investigated the effects of pulmonary rehabilitation based ERAS program (PREP) on post-operative pulmonary complications, pulmonary function, and health related quality of life following lung cancer surgery.
methodsThe PREP trial is a pragmatic, investigator-initiated, multi-center, randomized controlled, parallel group, clinical trial. Five hundred patients scheduled for minimally invasive pulmonary resection at six hospitals in China will be randomized with concealed allocation to receive either i) a pre-operative assessment and an information booklet or ii) a pre-operative assessment, an information booklet, plus an additional education, a 30-min pulmonary rehabilitation training session and the post-operative pulmonary rehabilitation program. The primary outcome is incidence of PPCs defined with the Melbourne Group Scale diagnostic scoring tool. Secondary outcomes include incidence of cardiopulmonary and other complications, pulmonary function, cardiopulmonary endurance, muscle strength, activity level, health-related quality of life (HRQoL), pre- and post-operative hospital length of stay (LOS), and total hospital LOS. DISCUSSION: The PREP trial is designed to verify the hypothesis that pulmonary rehabilitation based ERAS program reduces incidence of PPCs and improves pulmonary function and HRQoL in patients following lung cancer surgery. This trial will furthermore contribute significantly to the limited knowledge about the pulmonary rehabilitation based ERAS program following lung cancer surgery, and may thereby form the basis of future recommendations in the surgical community.
trial registrationChinese Clinical Trial Registry: ChiCTR1900024646, 21 July 2019.
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