ArticleBMC infectious diseases2020
Seroprevalence of Brucella infection and associated factors among pregnant women receiving antenatal care around human, wildlife and livestock interface in Ngorongoro ecosystem, Northern Tanzania. A cross-sectional study.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Meta-analysis of brucellosis and relative risks.Medicine · 2026Pooled it
- Seroprevalence, associated risk factors, and molecular detection of Brucella spp. in cattle, sheep, goats and humans in Mvomero district, Morogoro, Tanzania.One health outlook · 2026Article
- Human brucellosis in pregnancy in western Uganda: High seroprevalence and health risk factors identified in a cross-sectional study.PLoS neglected tropical diseases · 2026Article
- Serological diagnosis of human brucellosis in Morocco and prospects for advanced diagnostic techniques.Iranian journal of microbiology · 2025Article
- Article
- Some zoonotic infectious diseases are prevalent among children under 15 years of age in Ardabil Province, northern Iran.BMC infectious diseases · 2025Article
- Seroprevalence of Brucella Infection and Its Determinants Among Pregnant Women Attending Antenatal Care in Burao City: At the Human Livestock Interface in Northeast Somaliland, Somalia.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
- Seroprevalence and molecular detection of brucellosis among Pakistani women with spontaneous abortion.Frontiers in public health · 2024Article
- Immune Responses Potentially Involved in the Gestational Complications ofPathogens (Basel, Switzerland) · 2023Review
- High Seropositivity ofJournal of pregnancy · 2023Article
- Occurrence and risk factors of brucellosis among domestic animals: an artificial neural network approach.Tropical animal health and production · 2022Article
- Brucellosis testing patterns at health facilities in Arusha region, northern Tanzania.PloS one · 2022Article
- Circulating Brucella species in wild animals of the Serengeti ecosystem, Tanzania.One health outlook · 2021Article
- Performance characteristics and costs of serological tests for brucellosis in a pastoralist community of northern Tanzania.Scientific reports · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrucellosis is a zoonotic disease transmitted to humans through contact with infected animals, animal products or consumption of infected dairy products. Brucella infection during pregnancy is of special interest due to association with adverse pregnancy outcomes. This study determined the seroprevalence and factors associated with Brucella infection among pregnant women around the human-wildlife-livestock interface area in Ngorongoro ecosystem, Northern Tanzania.
methodsA facility-based cross-sectional study was conducted between May and June 2018 at six health facilities that provide antenatal services. Pregnant women receiving antenatal care were invited to participate. A structured questionnaire was used to collect socio-demographic and obstetric characteristics in addition to behavior and practices related to the occurrence of human brucellosis. The presence of serum immunoglobulin against Brucella was determined using Rose Bengal Plate Test (RBPT). The positive samples were further assayed for the presence of IgG and IgM using The enzyme-linkedimmunosorbent assay. Bivariate analysis was conducted to determine the variables associated with Brucella seropositivity. Multivariable logistic regression analysis was performed to examine the factors independently associations with Brucella seropositivity after adjustment for other explanatory variables.
resultsA total of 313 participants were enrolled in the study. The overall seroprevalence of Brucella infection was 10.9% (34/313) determined by Rose Bengal plate test. Of 34 positive individuals, 27(79.4%) and 8(23.5%) were positive in the ELISA specific for IgG and IgM Brucella antibodies respectively. Regular contact with manure (AOR 3.16, 95%CI 1.27-7.83) and preference for animal fresh milk (AOR 3.80, 95% CI 1.23-11.69), raw meat (AOR 2.58, 95% CI 1.14-5.81) and raw animal blood (AOR 2.71, 95% CI 1.15-6.35) increased the odds of being Brucella seropositive. Contact with the animal placenta were not associated with Brucella seropositivity after adjustment.
conclusionThis study has found that brucellosis is an important public health problem among pregnant women in areas with interactions of humans; livestock and wildlife. The risk of infection increased with the regular contact with manure and preference of raw foodstuffs like animal blood, meat, and milk. We emphasize the need for interventional strategies to reduce the risk of exposure.
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