ArticleStroke2020
APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study.
Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Biomarkers of post-stroke cognitive impairment-a systematic literature review.Frontiers in behavioral neuroscience · 2026Pooled it
- Associations Between Vascular Risk Factor Levels and Cognitive Decline Among Stroke Survivors.JAMA network open · 2023Pooled it
- High Plasma Polyamine Levels Are Associated With an Increased Risk of Poststroke Cognitive Impairment: A Multicenter Prospective Study From CATIS.Journal of the American Heart Association · 2025Trial
- Machine learning-based prediction of 3-6-month post-stroke cognitive impairment using acute-phase clinical data: a two-center retrospective prognostic modeling study.BMC medical informatics and decision making · 2026Article
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- Article
- Polygenic risk score and cluster-based analysis suggests links between type 2 diabetes and vascular dementia in the KARE study.Nature communications · 2025Article
- Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study.The Lancet regional health. Europe · 2025Article
- APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.BMC neurology · 2025Article
- Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study.Aging · 2025Article
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Cognitive Decline After First-Time Transient Ischemic Attack.JAMA neurology · 2025Article
- Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke.Frontiers in endocrinology · 2025Review
- Cerebral hypoperfusion reduces tau accumulation.Annals of clinical and translational neurology · 2025Article
- Infarct volume as a predictor and therapeutic target in post-stroke cognitive impairment.Frontiers in medicine · 2025Review
- A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury.Nature neuroscience · 2024Article
- Factors Associated With Post-Stroke Cognitive Impairment: A Narrative Review.Brain & NeuroRehabilitation · 2024Review
- Not So Transient?: A Narrative Review on Cognitive Impairment After Transient Ischemic Attack.Stroke · 2024Review
- Dementia after Ischemic Stroke, from Molecular Biomarkers to Therapeutic Options.International journal of molecular sciences · 2024Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Background and Purpose- APOE-ε4 genotype is a risk factor for sporadic Alzheimer disease and reduced recovery from brain injury. Since data on APOE genotype and dementia associated with transient ischemic attack/stroke are sparse, we determined the associations in a longitudinal population-based cohort. Methods- All patients with transient ischemic attack or stroke (2002-2012) in a defined population of 92 728 OxVASC (Oxford Vascular Study) had follow-up to 5-years. Pre-event and incident postevent dementia were ascertained through direct patient assessment and follow-up, supplemented by review of hospital/primary care records. Associations between pre- and post-event dementia and APOE genotype (ε4/ε4-homozygous and ε4/ε3-heterozygous versus ε3/ε3) were examined using logistic regression and Cox regression models, respectively, adjusted for age, sex, education, cerebrovascular burden (stroke severity, prior stroke, white matter disease), diabetes mellitus, and dysphasia. Results- Among 1767 genotyped patients (mean/SD age, 73.0/13.0 years, 901 [51%] male, 602 [34%] transient ischemic attack), 1058 (59.9%) were APOE-ε3/ε3, 403 (22.8%) were ε4/ε3 and 30 (1.7%) were ε4-homozygous. Homozygosity was associated with both pre-event (adjusted odds ratio, 5.81 [95% CI, 1.93-17.48];
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.