ReviewCritical reviews in biochemistry and molecular biology2020
New era of optogenetics: from the central to peripheral nervous system.
Review in Critical reviews in biochemistry and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Prelimbic cortex-basolateral amygdala glutamatergic circuit drives cancer-induced bone pain in mice.iScience · 2026Article
- Article
- ON-OFF nanopores for optical control of transmembrane ionic communication.Nature nanotechnology · 2025Article
- Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration.Burns & trauma · 2025Review
- A Systematic Review to Compare Electrical, Magnetic, and Optogenetic Stimulation for Peripheral Nerve Repair.Journal of hand surgery global online · 2024Review
- Emerging optogenetics technologies in biomedical applications.Smart medicine · 2023Review
- MicroLED/LED electro-optical integration techniques for non-display applications.Applied physics reviews · 2023Review
- Advances in optogenetic studies of depressive-like behaviors and underlying neural circuit mechanisms.Frontiers in psychiatry · 2022Review
- Macrophage Activation in the Dorsal Root Ganglion in Rats Developing Autotomy after Peripheral Nerve Injury.International journal of molecular sciences · 2021Article
- Optobiochemistry: Genetically Encoded Control of Protein Activity by Light.Annual review of biochemistry · 2021Review
- Epineural optogenetic activation of nociceptors initiates and amplifies inflammation.Nature biotechnology · 2021Article
- Optimized Protocol for Subcutaneous Implantation of Encapsulated Cells Device and Evaluation of Biocompatibility.Frontiers in bioengineering and biotechnology · 2021Article
- Minimally invasive neural stimulation with a novel ultra-sensitive step function opsin: implications and future directions.Journal of neurophysiology · 2020Article
- Selective optogenetic stimulation of efferent fibers in the vagus nerve of a large mammal.Brain stimulationArticle
- The application of optogenetics in traumatic brain injury research: A narrative review.Brain circulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Optogenetics has recently gained recognition as a biological technique to control the activity of cells using light stimulation. Many studies have applied optogenetics to cell lines in the central nervous system because it has the potential to elucidate neural circuits, treat neurological diseases and promote nerve regeneration. There have been fewer studies on the application of optogenetics in the peripheral nervous system. This review introduces the basic principles and approaches of optogenetics and summarizes the physiology and mechanism of opsins and how the technology enables bidirectional control of unique cell lines with superior spatial and temporal accuracy. Further, this review explores and discusses the therapeutic potential for the development of optogenetics and its capacity to revolutionize treatment for refractory epilepsy, depression, pain, and other nervous system disorders, with a focus on neural regeneration, especially in the peripheral nervous system. Additionally, this review synthesizes the latest preclinical research on optogenetic stimulation, including studies on non-human primates, summarizes the challenges, and highlights future perspectives. The potential of optogenetic stimulation to optimize therapy for peripheral nerve injuries (PNIs) is also highlighted. Optogenetic technology has already generated exciting, preliminary evidence, supporting its role in applications to several neurological diseases, including PNIs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.