ArticleInternational journal of molecular sciences2020
Topical Drug Delivery Systems Based on Bacterial Nanocellulose: Accelerated Stability Testing.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Dihydromyricetin-LoadedPharmaceutics · 2026Article
- Curcumin-loaded nanocarriers for dermatological applications: current advances and biomedical implications.EXCLI journal · 2026Review
- Green Synthesis of Curcumin-loaded Bacterial Nanocellulose for Topical Application: Preparation and In vivo Study.Pharmaceutical nanotechnology · 2026Article
- Single Polysaccharide Dissolvable Microneedles for Painless Local Anesthesia: Fabrication, Characterization, andACS biomaterials science & engineering · 2025Article
- Novel nanostructured lipid carriers with lurasidone hydrochloride for intranasal administration for improved bioavailability.Therapeutic delivery · 2025Article
- Modulating the Release Kinetics of Natural Product Actinomycin from Bacterial Nanocellulose Films and Their Antimicrobial Activity.Bioengineering (Basel, Switzerland) · 2024Article
- Development of Mupirocin-Impregnated Bacterial Cellulosic Transdermal Patches for the Management of Skin Infection.ACS omega · 2024Article
- Exploring the Drug-Loading and Release Ability of FucoPol Hydrogel Membranes.International journal of molecular sciences · 2023Article
- Insight into the Latest Medical Applications of Nanocellulose.Materials (Basel, Switzerland) · 2023Review
- Recent Development of Nanomaterials for Transdermal Drug Delivery.Biomedicines · 2023Review
- Preparation, Characterization, and Evaluation of Cytotoxicity of Fast Dissolving Hydrogel Based Oral Thin Films Containing Pregabalin and Methylcobalamin.Gels (Basel, Switzerland) · 2023Article
- Article
- Nanocellulose: Recent Advances Toward Biomedical Applications.Small science · 2023Article
- Anticancer properties of bacterial cellulose membrane containing ethanolic extract ofFrontiers in bioengineering and biotechnology · 2023Article
- Bioactive Bacterial Nanocellulose Membranes Enriched withMaterials (Basel, Switzerland) · 2022Article
- Chitin-Glucan Complex Hydrogels: Optimization of Gel Formation and Demonstration of Drug Loading and Release Ability.Polymers · 2022Article
- Investigation of boron nanosized particles prepared with various surfactants and chitosan in terms of physical stability and cell viability.Turkish journal of chemistry · 2022Article
- Cellulose and protein nanofibrils: Singular biobased nanostructures for the design of sustainable advanced materials.Frontiers in bioengineering and biotechnology · 2022Review
- Natural Polymers-Based Materials: A Contribution to a Greener Future.Molecules (Basel, Switzerland) · 2021Review
- Comparison of drug release behavior of bacterial cellulose loaded with ibuprofen and propranolol hydrochloride.RSC advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Bacterial nanocellulose (BNC) membranes have enormous potential as systems for topical drug delivery due to their intrinsic biocompatibility and three-dimensional nanoporous structure, which can house all kinds of active pharmaceutical ingredients (APIs). Thus, the present study investigated the long-term storage stability of BNC membranes loaded with both hydrophilic and lipophilic APIs, namely, caffeine, lidocaine, ibuprofen and diclofenac. The storage stability was evaluated under accelerated testing conditions at different temperatures and relative humidity (RH), i.e., 75% RH/40 °C, 60% RH/25 °C and 0% RH/40 °C. All systems were quite stable under these storage conditions with no significant structural and morphological changes or variations in the drug release profile. The only difference observed was in the moisture-uptake, which increased with RH due to the hydrophilic nature of BNC. Furthermore, the caffeine-loaded BNC membrane was selected for in vivo cutaneous compatibility studies, where patches were applied in the volar forearm of twenty volunteers for 24 h. The cutaneous responses were assessed by non-invasive measurements and the tests revealed good compatibility for caffeine-loaded BNC membranes. These results highlight the good storage stability of the API-loaded BNC membranes and their cutaneous compatibility, which confirms the real potential of these dermal delivery systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.