Evidence map›Paper›PMID 32069862›Full record

ArticleNutrients2020

Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.

Baolong Liu, Yizhu Lu, Xingyi Chen, Philma Glora Muthuraj, Xingzhi Li, Mahesh Pattabiraman, Janos Zempleni, Stephen D Kachman, Sathish Kumar Natarajan, Jiujiu Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 3 syntheses or guidelines pooled it, 152 citations in OpenAlex.

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  11. Comparative evaluation of isolation protocols forFrontiers in pharmacology · 2026
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Baolong LiuDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Yizhu LuDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Xingyi ChenDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.ORCID 0000-0002-2982-4690
Philma Glora MuthurajDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Xingzhi LiDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Mahesh PattabiramanDepartment of Chemistry, University of Nebraska-Kearney, Kearney, NE 68849, USA.
Janos ZempleniDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Stephen D KachmanDepartment of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Sathish Kumar NatarajanDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.ORCID 0000-0001-7491-8592
Jiujiu YuDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
University of Nebraska–Lincoln · USUniversity of Nebraska at Kearney · US

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
NIGMS NIH HHS P20 GM104320NIH HHS P20GM104320U.S. Department of Agriculture 1015948
6 · The paper itself

Abstract

Fulminant hepatic failure (FHF) is a rare, life-threatening liver disease with a poor prognosis. Administration of D-galactosamine (GalN) and lipopolysaccharide (LPS) triggers acute liver injury in mice, simulating many clinical features of FHF in humans; therefore, this disease model is often used to investigate potential therapeutic interventions to treat FHF. Recently, suppression of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome, was shown to alleviate the severity of GalN/LPS-induced liver damage in mice. Therefore, the goal of this study was to find dietary exosome-like nanoparticles (ELNs) with therapeutic potential in curbing FHF by suppressing the NLRP3 inflammasome. Seven commonly consumed mushrooms were used to extract ELNs. These mushrooms were found to contain ELNs composed of RNAs, proteins, and lipids. Among these mushroom-derived ELNs, only shiitake mushroom-derived ELNs (S-ELNs) substantially inhibited NLRP3 inflammasome activation by preventing inflammasome formation in primary macrophages. S-ELNs also suppressed the secretion of interleukin (IL)-6, as well as both protein and mRNA levels of the

Indexed as

AnimalsChemical and Drug Induced Liver InjuryDisease Models, AnimalExosomesGalactosamineLipopolysaccharidesLiverLiver Failure, AcuteMacrophagesMiceNanoparticlesNLR Family, Pyrin Domain-Containing 3 ProteinPlant ExtractsProtective AgentsShiitake MushroomsGalactosamineLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinPlant ExtractsProtective Agentsexosomesfulminant hepatic failureinflammationnanoparticlesNLRP3 inflammasomeshiitake mushrooms

Identifiers

PMID32069862
PMCPMC7071144
OpenAlexW3005960150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.