Evidence map›Paper›PMID 32069422›Full record

ArticleMolecular pharmaceutics2020

Detecting TRA-1-60 in Cancer via a Novel Zr-89 Labeled ImmunoPET Imaging Agent.

Jordan M White, Akhila N Kuda-Wedagedara, Madison N Wicker, Daniel E Spratt, William M Schopperle, Elisabeth Heath, Nerissa T Viola

Open access · greenAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Selective ablation of TRA-1-60Theranostics · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jordan M WhiteDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan 48201, United States.ORCID 0000-0003-0989-586X
Akhila N Kuda-WedagedaraDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
Madison N WickerDepartment of Biology, University of Michigan - Flint, Flint, Michigan 48502, United States.
Daniel E SprattDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, United States.
William M SchopperleCureMeta LLC, Boston, Massachusetts 02210, United States.
Elisabeth HeathDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
Nerissa T ViolaDepartment of Oncology, Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
The Barbara Ann Karmanos Cancer Institute · USUniversity of Michigan · USUniversity of Michigan–Flint · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
TRAINING PROGRAM IN THE BIOLOGY OF CANCERT32CA009531 · NCI · WAYNE STATE UNIVERSITY · PI Larry H Matherly · 1985 to 2026
$5.3M
NCI NIH HHS P30 CA022453NCI NIH HHS T32 CA009531
6 · The paper itself

Abstract

TRA-1-60 (TRA) is a cell-surface antigen implicated in drug resistance, relapse, and recurrence. Its expression has been reported in breast, prostate, pancreatic, ovarian tumors, and follicular lymphoma, which paved the development of the therapeutic antibody, Bstrongomab (Bsg), and its drug conjugates. Because patient selection is critical to achieve clinical benefit, a noninvasive imaging agent to select TRA+ lesions in patients is needed. Herein, we report the development of the immunopositron emission tomography (immunoPET) radiotracer

Indexed as

AnimalsAntigens, SurfaceCell Line, TumorChelating AgentsDeferoxamineHumansImmunoconjugatesMaleMiceMice, NudePancreatic NeoplasmsPC-3 CellsPositron-Emission TomographyProstatic NeoplasmsProteoglycansRadioisotopesAntigens, SurfaceChelating AgentsDeferoxamineImmunoconjugatesProteoglycansRadioisotopesTRA-1-60 antigen, humanZirconiumZirconium-89immunopositron emission tomographymetastasisTRA-1−60tumor initiating cells

Identifiers

PMID32069422
PMCPMC7249247
OpenAlexW3008320817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.