Evidence map›Paper›PMID 32069391›Full record

ArticleACS infectious diseases2020

Assessment of Biological Role and Insight into Druggability of the

Alexander J Polino, Armiyaw S Nasamu, Jacquin C Niles, Daniel E Goldberg

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  13. In Silico Studies of Four Compounds ofMolecules (Basel, Switzerland) · 2023
    Article
  14. Knock-sideways by inducible ER retrieval enables a unique approach for studyingProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexander J PolinoDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Armiyaw S NasamuDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Jacquin C NilesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-6250-8796
Daniel E GoldbergDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.ORCID 0000-0003-3529-8399
Washington University in St. Louis · USMassachusetts Institute of Technology · US

Funding

MIT Center for Integrative Synthetic BiologyP50GM098792 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISS, RON · 2013 to 2017
$11.0M
Plasmepsin X function in PlasmodiumR01AI138447 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2018 to 2022
$1.9M
IDENTIFICATION OF THE ANTIMALARIAL TARGET OF PEPSTATIN ESTERSR01AI112508 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2014 to 2018
$1.9M
NIAID NIH HHS R01 AI112508NIGMS NIH HHS P50 GM098792
6 · The paper itself

Abstract

Upon infecting a red blood cell (RBC), the malaria parasite

Indexed as

Aspartic Acid EndopeptidasesCRISPR-Cas SystemsErythrocytesHumansInhibitory Concentration 50Life Cycle StagesPlasmodium falciparumProtein Processing, Post-TranslationalProtozoan ProteinsAspartic Acid EndopeptidasesplasmepsinProtozoan Proteinsaspartic proteaseCRISPR/Cas9dense granuleknockdownmalariaprotein export

Identifiers

PMID32069391
PMCPMC7155168
OpenAlexW3007890217

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.