Evidence map›Paper›PMID 32069352›Full record

Trial reportThe American journal of clinical nutrition2020

Leptin partially mediates the association between early-life nutritional supplementation and long-term glycemic status among women in a Guatemalan longitudinal cohort.

Siran He, Ngoc-Anh Le, Manuel Ramirez-Zea, Reynaldo Martorell, K M Venkat Narayan, Aryeh D Stein

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
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  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Siran HeNutrition and Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.
Ngoc-Anh LeBiomarker Core Laboratory, Foundation for Atlanta Veterans Education and Research, Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA.
Manuel Ramirez-ZeaINCAP Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala.
Reynaldo MartorellRollins School of Public Health, Emory University, Atlanta, GA, USA.
K M Venkat NarayanRollins School of Public Health, Emory University, Atlanta, GA, USA.
Aryeh D SteinRollins School of Public Health, Emory University, Atlanta, GA, USA.
Emory University · USAtlanta Research and Education Foundation · USInstitute of Nutrition of Central America and Panama · GT

Funding

Early childhood nutrition and adult metabolomic and cardiometabolic profilesR01HD075784 · NICHD · EMORY UNIVERSITY · PI STEIN, ARYEH DAVID · 2014 to 2018
$2.7M
NICHD NIH HHS R01 HD075784
6 · The paper itself

Abstract

backgroundEarly-life exposure to improved nutrition is associated with decreased risk of diabetes but increased risk of obesity. Leptin positively correlates with adiposity and has glucose-lowering effects, thus it may mediate the association of early-life nutrition and long-term glycemic status.

objectivesWe aimed to investigate the role of leptin in the differential association between early-life nutrition and the risks of obesity and diabetes.

methodsWe analyzed data from a Guatemalan cohort who were randomly assigned at the village level to receive nutritional supplements as children. We conducted mediation analysis to examine the role of leptin in the associations of early-life nutrition and adult cardiometabolic outcomes.

resultsAmong 1112 study participants aged (mean ± SD) 44.1 ± 4.2 y, 60.6% were women. Cardiometabolic conditions were common: 40.2% of women and 19.4% of men were obese, and 53.1% of women and 41.0% of men were hyperglycemic or diabetic. Median (IQR) leptin concentration was 15.2 ng/mL (10.2-17.3 ng/mL) in women and 2.7 ng/mL (1.3-5.3 ng/mL) in men. Leptin was positively correlated with BMI (Spearman's ρ was 0.6 in women, 0.7 in men). Women exposed to improved nutrition in early life had 2.8-ng/mL (95% CI: 0.3, 5.3 ng/mL) higher leptin and tended to have lower fasting glucose (-0.8 mmol/L; -1.8, 0.2 mmol/L, nonsignificant) than unexposed women. There were no significant differences in leptin (-0.7 ng/mL; -2.1, 0.8 ng/mL) or fasting glucose (0.2 mmol/L; -0.5, 0.9 mmol/L) in men exposed to improved nutrition in early life compared with unexposed men. Leptin mediated 34.9% of the pathway between early-life nutrition and fasting glucose in women. The mediation in women was driven by improved pancreatic β-cell function. We did not observe the mediation effect in men.

conclusionsLeptin mediated the glucose-lowering effect of early-life nutrition in women but not in men.

Indexed as

AdiposityAdultBlood GlucoseBody Mass IndexCohort StudiesDietary SupplementsFemaleGlycemic IndexGuatemalaHumansInsulinLeptinLongitudinal StudiesMaleMiddle AgedObesityBlood GlucoseInsulinLeptinfirst 1000 daysglucosehomeostasis model assessmentinsulin resistanceleptinlife cyclemediation analysisnutritional status

Identifiers

PMID32069352
PMCPMC7138657
OpenAlexW3008944280

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.