ArticlePLoS neglected tropical diseases2020
Genomic epidemiology of Vibrio cholerae reveals the regional and global spread of two epidemic non-toxigenic lineages.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 29 citations in OpenAlex.
- Whole Genome Characterisation of Non-O1/Non-O139Microorganisms · 2026Article
- Genomic and epidemiological insights into a non-toxigenic Vibrio cholerae O1 Ogawa from an autochthonous case in Brazil.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Genomic diversity and antimicrobial resistance ofMicrobial genomics · 2025Article
- Non-O1/O139 environmental Vibrio cholerae from Northern Cameroon reveals potential intra-/inter-continental transmissions.PLoS neglected tropical diseases · 2025Article
- Recent Discovery of Diverse Prophages Located in Genomes ofFoods (Basel, Switzerland) · 2025Review
- Non-toxigenicArchive of clinical cases · 2025Review
- Emergence of multidrug resistant, ctx negative seventh pandemic Vibrio cholerae O1 El Tor sequence type (ST) 69 in coastal water of Kerala, India.Scientific reports · 2024Article
- Spotlight on the epidemiology and antimicrobial susceptibility profiles ofFuture microbiology · 2024Review
- Emergence and genomic insights of non-pandemic O1Microbiology spectrum · 2023Article
- Genomic epidemiology reveals multidrug resistant plasmid spread between Vibrio cholerae lineages in Yemen.Nature microbiology · 2023Article
- Genomic diversity of Yersinia pestis from Yunnan Province, China, implies a potential common ancestor as the source of two plague epidemics.Communications biology · 2023Article
- Article
- Genomic and Evolutionary Insights into Australian Toxigenic Vibrio cholerae O1 Strains.Microbiology spectrum · 2023Article
- Whole Genome Analysis of a Non-O1, Non-O139Infection and drug resistance · 2023Article
- Virulence and resistance patterns ofFrontiers in microbiology · 2023Article
- Population genomics of the food-borne pathogenMicrobial genomics · 2022Article
- Cholera Caused by a New Clone of Serogroup O1China CDC weekly · 2022Article
- Genetic diversity and transmission patterns ofMicrobial genomics · 2021Article
- Emergence of Vibrio cholerae O1 Sequence Type 75, South Africa, 2018-2020.Emerging infectious diseases · 2021Article
- Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae.Nature communications · 2020Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-toxigenic Vibrio cholerae isolates have been found associated with diarrheal disease globally, however, the global picture of non-toxigenic infections is largely unknown. Among non-toxigenic V. cholerae, ctxAB negative, tcpA positive (CNTP) isolates have the highest risk of disease. From 2001 to 2012, 71 infectious diarrhea cases were reported in Hangzhou, China, caused by CNTP serogroup O1 isolates. We sequenced 119 V. cholerae genomes isolated from patients, carriers and the environment in Hangzhou between 2001 and 2012, and compared them with 850 publicly available global isolates. We found that CNTP isolates from Hangzhou belonged to two distinctive lineages, named L3b and L9. Both lineages caused disease over a long time period with usually mild or moderate clinical symptoms. Within Hangzhou, the spread route of the L3b lineage was apparently from rural to urban areas, with aquatic food products being the most likely medium. Both lineages had been previously reported as causing local endemic disease in Latin America, but here we show that global spread of them has occurred, with the most likely origin of L3b lineage being in Central Asia. The L3b lineage has spread to China on at least three occasions. Other spread events, including from China to Thailand and to Latin America were also observed. We fill the missing links in the global spread of the two non-toxigenic serogroup O1 V. cholerae lineages that can cause human infection. The results are important for the design of future disease control strategies: surveillance of V. cholerae should not be limited to ctxAB positive strains.
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