ArticlePLoS neglected tropical diseases2020
Rickettsia felis identified in two fatal cases of acute meningoencephalitis.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Simultaneous serological assessment of four zoonotic rickettsiae among dogs near the United States-Mexico border.PLoS neglected tropical diseases · 2026Article
- Case Report: PediatricFrontiers in pediatrics · 2026Article
- Article
- Rickettsia felis meningoencephalitis in a 10-year-old child: a case report and literature review.BMC pediatrics · 2025Review
- Central infection with Rickettsia felis complicated with stroke: A case series and review.IDCases · 2025Article
- Article
- Dog ectoparasites as sentinels for pathogenic Rickettsia and Bartonella in rural Guatemala.Acta tropica · 2024Article
- The detection of zoonotic microorganisms inFrontiers in veterinary science · 2024Article
- Metagenomics of culture isolates and insect tissue illuminate the evolution ofMicrobial genomics · 2023Article
- Identification of Vietnamese Flea Species and Their Associated Microorganisms Using Morphological, Molecular, and Protein Profiling.Microorganisms · 2023Article
- Diagnosis of Two Meningitis Cases Caused by Rickettsia Felis in China, with Metagenomic Next-Generation Sequencing: A Case Report.Infection and drug resistance · 2023Article
- Molecular Detection of Rickettsia felis in Fleas of Companion Animals in East Texas.The American journal of tropical medicine and hygiene · 2022Article
- The role of cofeeding arthropods in the transmission of Rickettsia felis.PLoS neglected tropical diseases · 2022Article
- Culture Isolate ofInternational journal of environmental research and public health · 2022Article
- HumanFrontiers in cellular and infection microbiology · 2022Article
- Dynamic gene expression in salivary glands of the cat flea during Rickettsia felis infection.Pathogens and disease · 2021Article
- Neglected human Rickettsia felis infection in Taiwan: A retrospective seroepidemiological survey of patients with suspected rickettsioses.PLoS neglected tropical diseases · 2021Article
- Review
- Manifestations and Management of Flea-Borne Rickettsioses.Research and reports in tropical medicine · 2021Review
- Molecular detection of pathogens in ticks and fleas collected from companion dogs and cats in East and Southeast Asia.Parasites & vectors · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRickettsia felis has recently emerged worldwide as a cause of human illness. Typically causing mild, undifferentiated fever, it has been implicated in several cases of non-fatal neurological disease in Mexico and Sweden. Its distribution and pathogenicity in Southeast Asia is poorly understood. METHODOLOGY/PRINCIPAL
findingsWe retroactively tested cerebrospinal fluid (CSF) or sera from 64 adult patients admitted to hospital in North Sulawesi, Indonesia with acute neurological disease. Rickettsia felis DNA was identified in the CSF of two fatal cases of meningoencephalitis using multi-locus sequence typing semi-nested PCR followed by Sanger sequencing. DNA from both cases had 100% sequence homologies to the R. felis reference strain URRWXCal2 for the 17-kDa and ompB genes, and 99.91% to gltA. CONCLUSION/SIGNIFICANCE: The identification of R. felis in the CSF of two fatal cases of meningoencephalitis in Indonesia suggests the distribution and pathogenicity of this emerging vector-borne bacteria might be greater than generally recognized. Typically Rickettsia are susceptible to the tetracyclines and greater knowledge of R. felis endemicity in Indonesia should lead to better management of some acute neurological cases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.