ArticleMedical science monitor : international medical journal of experimental and clinical research2020
Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Disrupted neurovascular coupling in patients with lung cancer after chemotherapy.Quantitative imaging in medicine and surgery · 2025Article
- Longitudinal changes of regional spontaneous brain activity in nasopharyngeal carcinoma patients receiving chemoradiotherapy.Frontiers in neuroscience · 2025Article
- Altered trends of local brain function in classical trigeminal neuralgia patients after a single trigger pain.BMC medical imaging · 2024Article
- Preoperative early-stage lung cancer patients and local brain area changes: a cross-sectional observational descriptive study.Frontiers in psychology · 2024Article
- Alteration of brain network centrality in CTN patients after a single triggering pain.Frontiers in neuroscience · 2023Article
- Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: a resting state fMRI study.Brain imaging and behavior · 2022Article
- Functional changes of the prefrontal cortex, insula, caudate and associated cognitive impairment (chemobrain) in NSCLC patients receiving different chemotherapy regimen.Frontiers in oncology · 2022Article
- Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting-state functional magnetic resonance imaging study.Frontiers in oncology · 2022Article
- Changes in resting-state measures of prostate cancer patients exposed to androgen deprivation therapy.Scientific reports · 2021Article
- Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy.Frontiers in neurology · 2021Article
- Altered Static and Dynamic Interhemispheric Resting-State Functional Connectivity in Patients With Thyroid-Associated Ophthalmopathy.Frontiers in neuroscience · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Few studies have examined functional brain changes specifically associated with chemotherapy (CTx) in patients with lung cancer. This prospective longitudinal research aimed to explore the change in intrinsic brain activity by investigating patients with lung cancer after CTx. MATERIAL AND METHODS Sixteen patients and 20 healthy individuals were enrolled in this study. The amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), dynamic amplitude of low-frequency fluctuation (dALFF), and dynamic regional homogeneity (dReHo) were computed. The group differences in resting state functional magnetic resonance imaging (rs-fMRI) parameters were compared. Alterations in the rs-fMRI parameters from before CTx to after CTx were assessed using the paired t-test. We performed correlation analyses between rs-fMRI parameters and Montreal Cognitive Assessment (MoCA) scores. RESULTS We found statistically significant differences in MoCA scores before CTx and after CTx. Compared to the healthy group, rs-fMRI values decreased in the frontal regions as well as parietal regions compared to values before CTx. In addition, we found significantly decreased rs-fMRI values in the default-mode network (DMN) region of the brain before CTx compared to after CTx. We found no significant correlations between altered intrinsic activity values and MoCA scores. CONCLUSIONS The current study indicated that patients with lung cancer after CTx had decreased dynamic brain activity in the DMN region, and the DMN is vulnerable when patients undergoing CTx.
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