Evidence map›Paper›PMID 32068893›Full record

ArticleThe British journal of dermatology2020

The European TREatment of ATopic eczema (TREAT) Registry Taskforce survey: prescribing practices in Europe for phototherapy and systemic therapy in adult patients with moderate-to-severe atopic eczema.

F M Vermeulen, L A A Gerbens, J Schmitt, M Deleuran, A D Irvine, K Logan, W Ouwerkerk, C Vestergaard, C Flohr, P I Spuls and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The British journal of dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Phototherapy for atopic eczema.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Trial
  4. Article
  5. Observational
  6. Happiness across the borders-A cross-sectional study among patients with psoriasis and atopic dermatitis in Europe.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  7. International consensus on methotrexate dosing for patients with atopic dermatitis: An eDelphi study.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

F M VermeulenDepartment of Dermatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Meibergdreef 9, Amsterdam, the Netherlands.ORCID 0000-0002-6333-3334
L A A GerbensDepartment of Dermatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Meibergdreef 9, Amsterdam, the Netherlands.ORCID 0000-0002-5244-5058
J SchmittCentre for Evidence-Based Healthcare, Medizinische Fakultät Carl Gustav Carus, TU Dresden, Dresden, Germany.ORCID 0000-0003-0264-0960
M DeleuranDepartment of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-0593-9925
A D IrvineDepartment of Paediatric Dermatology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.ORCID 0000-0002-9048-2044
K LoganThe Paediatric Allergy Research Group, the Department of Women and Children's Health, King's College London, London, UK.
W OuwerkerkDepartment of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Infection & Immunity Institute, Cancer Center Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-2000-9358
C VestergaardDepartment of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6485-3158
C FlohrNational Heart Centre Singapore, Singapore.ORCID 0000-0003-4884-6286
P I SpulsDepartment of Dermatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Meibergdreef 9, Amsterdam, the Netherlands.ORCID 0000-0002-6035-2863
international TREAT Registry Taskforce
Amsterdam University Medical Centers · NLAarhus University Hospital · DKNational Heart Centre Singapore · SGKing's College London · GBTrinity College Dublin · IEUniversity Hospital Carl Gustav Carus · DE

Funding

Department of Health CDF-2014-07-037European Academy of Dermatology and Venereology 2016-034
6 · The paper itself

Abstract

backgroundFor many years dermatologists have had access to few therapies for patients with moderate-to-severe atopic eczema (AE). New promising therapies are entering the market but conventional phototherapies and systemic therapies have more well-known safety profiles, lower costs and wider availability.

objectivesTo provide insight into current prescribing practices of conventional phototherapy and systemic immunomodulatory therapies for adults with chronic AE, and the factors influencing these prescribing practices, before biologics and other novel therapeutics become routine clinical practice.

methodsIn this exploratory study dermatologists were invited to participate in an online survey via a mailing list of the European Academy of Dermatology and Venereology and national societies. Data were collected on participant characteristics (including clinical practice data), the use of phototherapies and systemic therapies, and factors influencing their use.

resultsFrom 30 European countries, 238 out of 361 dermatologists willing to participate (65·9%) completed the survey, with 229 meeting the inclusion criteria. For phototherapy (prescribed by 84·7%), most preferred narrowband ultraviolet B as first line (80·9%) and psoralen plus ultraviolet A as second (21·6%). For systemic therapy (prescribed by 95·2%) ciclosporin (54·1%), oral corticosteroids (32·6%) and methotrexate (30·7%) were used first line. Dermatologists relied mostly on personal experience for prescribing phototherapy and systemic therapy. Azathioprine and mycophenolic acid were prescribed by only 135 (59·0%) and 85 (37·1%) participants in total, mostly due to a lack of personal experience.

conclusionsThis study provides insight into prescribing practices for conventional phototherapy and systemic therapy in Europe and shows that off-label therapies are also preferred as first-line choice of systemic therapy.

Indexed as

Dermatitis, AtopicAdultCyclosporineEuropeHumansPhototherapyRegistriesCyclosporine

Identifiers

PMID32068893
PMCPMC7754420
OpenAlexW3008042106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.