Evidence map›Paper›PMID 32068776›Full record

ArticleThe American journal of clinical nutrition2020

Associations between human milk oligosaccharides and growth in infancy and early childhood.

Hanna Lagström, Samuli Rautava, Helena Ollila, Anne Kaljonen, Olli Turta, Johanna Mäkelä, Chloe Yonemitsu, Julia Gupta, Lars Bode

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Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanna LagströmDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland.
Samuli RautavaDepartment of Pediatrics, University of Turku & Turku University Hospital, Turku, Finland.
Helena OllilaDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland.
Anne KaljonenDepartment of Biostatistics, Faculty of Medicine, University of Turku, Turku, Finland.
Olli TurtaDepartment of Pediatrics, University of Turku & Turku University Hospital, Turku, Finland.
Johanna MäkeläFinnish Clinical Biobank Tampere, Tampere University Hospital, Tampere, Finland.
Chloe YonemitsuDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, USA.
Julia GuptaDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, USA.
Lars BodeDepartment of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California San Diego, La Jolla, CA, USA.

Funding

Exploring Associations between Human Milk Oligosaccharides and Growth, Body Composition and Obesity Risk in Infancy and Early ChildhoodR21HD088953 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BODE, LARS · 2017 to 2018
$415k
NICHD NIH HHS R21 HD088953
6 · The paper itself

Abstract

backgroundBreastfeeding modulates infant growth and protects against the development of obesity. However, whether or not maternal variation in human milk components, such as human milk oligosaccharides (HMOs), is associated with programming of child growth remains unknown.

objectiveOur objective was to determine the association between maternal HMO composition and child growth during the first 5 y of life. In addition, the association between maternal prepregnancy BMI and HMO composition was assessed.

methodsHuman milk samples from 802 mothers were obtained from a prospective population-based birth cohort study, Steps to healthy development of Children (STEPS), conducted in Turku, Finland. HMO composition in these milk samples was analyzed by HPLC. Child growth data from 3 mo to 5 y were collected from municipal well-baby clinics and linked to maternal HMO composition data to test for associations.

resultsMaternal HMO composition 3 mo after delivery was associated with height and weight during the first 5 y of life in children of secretor mothers. Specifically, HMO diversity and the concentration of lacto-N-neo-tetraose (LNnT) were inversely associated and that of 2'-fucosyllactose (2'FL) was directly associated with child height and weight z scores in a model adjusted for maternal prepregnancy BMI, mode of delivery, birthweight z score, sex, and time. Maternal prepregnancy BMI was associated with HMO composition.

conclusionsThe association between maternal HMO composition and childhood growth may imply a causal relation, which warrants additional testing in preclinical and clinical studies, especially since 2'FL and LNnT are among the HMOs now being added to infant formula. Furthermore, altered HMO composition may mediate the impact of maternal prepregnancy BMI on childhood obesity, which warrants further investigation to establish the cause-and-effect relation.

Indexed as

Child DevelopmentAdultBody HeightBody WeightBreast FeedingChild, PreschoolFemaleFinlandHumansInfantLongitudinal StudiesMaleMilk, HumanOligosaccharidesProspective StudiesYoung AdultOligosaccharidesbreastfeedingchildhood growthhuman milk oligosaccharidesinfant growthmaternal BMI

Identifiers

PMID32068776
PMCPMC7138667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.