ArticleThe American journal of gastroenterology2020
Multitarget Stool DNA Screening in Clinical Practice: High Positive Predictive Value for Colorectal Neoplasia Regardless of Exposure to Previous Colonoscopy.
Article in The American journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Quality indicators for colonoscopy.Gastrointestinal endoscopy · 2024Guideline
- Outcomes and Characteristics Across Age Groups of Patients with Positive MT-sDNA Stool Tests: Data from the New Hampshire Colonoscopy Registry.Digestive diseases and sciences · 2026Article
- Anatomical location of colorectal neoplasia in patients with positive stool test (multitarget stool deoxyribonucleic acid or fecal immunochemical test) results: data from the New Hampshire Colonoscopy Registry.Gastrointestinal endoscopy · 2026Article
- Stool DNA-based SDC2 Methylation Test for the Screening of Colorectal Neoplasia in an Asymptomatic, Average-Risk Population.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2026Article
- Multitarget Stool DNA Testing for Colorectal Cancer Screening in Clinical Practice.The American journal of gastroenterology · 2025Article
- Anatomical Distribution of Polyps Is Different for Men and Women With Positive Stool Tests.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Explaining the Correlates of the Multi-Theory Model (MTM) of Health Behavior Change in Visual (Structural) Colorectal Cancer Screening Examinations.International journal of environmental research and public health · 2025Article
- Stool-based methylated syndecan-2 testing has a high positive predictive value in an average/increased-risk population: a multicenter retrospective study.Gastroenterology report · 2025Article
- Effects of Oral Anticoagulant and Antiplatelet Agents on Performance of Multitarget Colorectal Cancer Screening Test.Gastro hep advances · 2025Article
- Quality Indicators for Colonoscopy.The American journal of gastroenterology · 2024Article
- Detecting colorectal cancer using genetic and epigenetic biomarkers: screening and diagnosis.Journal of medicine and life · 2024Review
- Neoplasia Diagnosis After Multi-target Stool DNA Is Enhanced Among Lowest Baseline Detectors.Digestive diseases and sciences · 2023Article
- Positive Predictive Value for Multitarget Stool DNA After Bariatric and Metabolic Surgery.Gastro hep advances · 2023Article
- Value of faecal exfoliated cells in colorectal tumour screening using SDC2 methylation test.Annals of medicine · 2023Article
- Optimal Strategies for Colorectal Cancer Screening.Current treatment options in oncology · 2022Review
- Novel Diagnostic Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2022Review
- High Positive Predictive Value of Multitarget Stool DNA After Aerodigestive Tract Radiotherapy.Gastro hep advances · 2022Article
- [Value of combined detection of ITGA4 and SFRP2 gene methylation in stool DNA in diagnosis and prognostic evaluation of colorectal tumors].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Detection of Postcolonoscopy Colorectal Neoplasia by Multi-target Stool DNA.Clinical and translational gastroenterology · 2021Article
- Colorectal Cancer Screening With the Multitarget Stool DNA Test.The American journal of gastroenterology · 2020Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesMultitarget stool DNA (MT-sDNA) testing has grown as a noninvasive screening modality for colorectal cancer (CRC), but real-world clinical data are limited in the post-FDA approval setting. The effect of previous colonoscopy on MT-sDNA performance is not known. We aimed to evaluate findings of colorectal neoplasia (CRN) at diagnostic colonoscopy in patients with positive MT-sDNA testing, stratified by patient exposure to previous colonoscopy.
methodsWe identified consecutive patients completing MT-sDNA testing over a 39-month period and reviewed the records of those with positive tests for neoplastic findings at diagnostic colonoscopy. MT-sDNA test positivity rate, adherence to diagnostic colonoscopy, and the positive predictive value (PPV) of MT-sDNA for any CRN and neoplastic subtypes were calculated.
resultsOf 16,469 MT-sDNA tests completed, testing returned positive in 2,326 (14.1%) patients. After exclusion of patients at increased risk for CRC, 1,801 patients remained, 1,558 (87%) of whom underwent diagnostic colonoscopy; 918 of 1,558 (59%) of these patients had undergone previous colonoscopy, whereas 640 (41%) had not. Any CRN was found in 1,046 of 1,558 patients (PPV = 67%). More neoplastic lesions were found in patients without previous colonoscopy (73%); however, the rates remained high among those who had undergone previous colonoscopy (63%, P < 0.0001). The large majority (79%) of patients had right-sided neoplasia. DISCUSSION: MT-sDNA has a high PPV for any CRN regardless of exposure to previous colonoscopy. Right-sided CRN was found at colonoscopy in most patients with positive MT-sDNA testing, representing a potential advantage over other currently available screening modalities for CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.