ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020
On the nature of high-amplitude propagating pressure waves in the human colon.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 45 citations in OpenAlex.
- High amplitude propagated contractions with Glycerin versus Bisacodyl: A within-subject comparison in children undergoing colonic manometry.Neurogastroenterology and motility · 2023Trial
- Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry.Neurogastroenterology and motility · 2022Trial
- A Biophysical Model of Human Colonic Motor Pattern Generation in Health and Disease.bioRxiv : the preprint server for biology · 2026Article
- Physiology of lower gastrointestinal tract.Alimentary pharmacology & therapeutics · 2024Review
- Ingesting yeast extract causes excitation of neurogenic and myogenic colonic motor patterns in the rat.Journal of cellular and molecular medicine · 2024Article
- Simultaneous Colonic Pressure Waves in Children and Young Adults with Gastrointestinal Motility Disorders: Artefact or Colonic Physiology?Journal of clinical medicine · 2023Article
- Altered Gut Microbic Flora and Haemorrhoids: Could They Have a Possible Relationship?Journal of clinical medicine · 2023Article
- Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation.Scientific reports · 2022Article
- The role of colonic motility in low anterior resection syndrome.Frontiers in oncology · 2022Review
- Modulation of the autonomic nervous system by one session of spinal low-level laser therapy in patients with chronic colonic motility dysfunction.Frontiers in neuroscience · 2022Article
- The Sphincter of O'Beirne - Part 1: Study of 18 Normal Subjects.Digestive diseases and sciences · 2021Article
- The Sphincter of O'Beirne-Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia.Digestive diseases and sciences · 2021Article
- Luminal Fluid Motion Inside an In Vitro Dissolution Model of the Human Ascending Colon Assessed Using Magnetic Resonance Imaging.Pharmaceutics · 2021Article
- Trans-illumination intestine projection imaging of intestinal motility in mice.Nature communications · 2021Article
- High-Resolution Colonic Manometry Pressure Profiles Are Similar in Asymptomatic Diverticulosis and Controls.Digestive diseases and sciences · 2021Article
- The Pressure's on: Finding the Cause of Diverticula Formation.Digestive diseases and sciences · 2021Article
- The Defecation Reflex Assessed by High-Resolution Colonic Manometry.Journal of the Canadian Association of Gastroenterology · 2021Article
- Optimizing Autonomic Function Analysis via Heart Rate Variability Associated With Motor Activity of the Human Colon.Frontiers in physiology · 2021Article
- Distal Colon Motor Coordination: The Role of the Coloanal Reflex and the Rectoanal Inhibitory Reflex in Sampling, Flatulence, and Defecation.Frontiers in medicine · 2021Article
- Transient Anal Sphincter Relaxations Are a Normal Phenomenon in Healthy Subjects.Journal of neurogastroenterology and motility · 2020Article
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5 authors at 1 institution in 1 country.
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Abstract
Characterization of high-amplitude propagating pressure waves (HAPWs or HAPCs) plays a key role in diagnosis of colon dysmotility using any type of colonic manometry. With the introduction of high-resolution manometry, more insight is gained into this most prominent propulsive motor pattern. Here, we use a water-perfused catheter with 84 sensors with intervals between measuring points of 1 cm throughout the colon, for 6-8 h, in 19 healthy subjects. The catheter contained a balloon to evoke distention. We explored as stimuli a meal, balloon distention, oral prucalopride, and bisacodyl injection, with a goal to optimally evoke HAPWs. We developed a quantitative measure of HAPW activity, the "HAPW Index." Our protocol elicited 290 HAPWs. 21% of HAPWs were confined to the proximal colon with an average amplitude of 75.3 ± 3.3 mmHg and an average HAPW Index of 440 ± 58 mmHg·m·s. 29% of HAPWs started in the proximal colon and ended in the transverse or descending colon, with an average amplitude of 87.9 ± 3.1 mmHg and an average HAPW Index of 3,344 ± 356 mmHg·m·s. Forty-nine percent of HAPWs started and ended in the transverse or descending colon with an average amplitude of 109.3 ± 3.3 mmHg and an average HAPW Index of 2,071 ± 195 mmHg·m·s. HAPWs with and without simultaneous pressure waves (SPWs) initiated the colo-anal reflex, often abolishing 100% of anal sphincter pressure. Rectal bisacodyl and proximal balloon distention were the most optimal stimuli to evoke HAPWs. These measures now allow for a confident diagnosis of abnormal motility in patients with colonic motor dysfunction.
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