ArticleHormones and behavior2020
Sex differences in vasopressin 1a receptor regulation of social communication within the lateral habenula and dorsal raphe of mice.
Article in Hormones and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders.Frontiers in behavioral neuroscience · 2021Pooled it
- Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain.eLife · 2026Article
- Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- Neuronal Properties in the Lateral Habenula and Adult-Newborn Interactions in Virgin Female and Male Mice.eNeuro · 2025Article
- Altered vocal communication in adult vasopressin-deficient Brattleboro rats.Physiology & behavior · 2024Article
- A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes.Biology of sex differences · 2024Article
- A vasopressin circuit that modulates sex-specific social interest and anxiety-like behavior in mice.bioRxiv : the preprint server for biology · 2023Article
- Sex differences in afferents and efferents of vasopressin neurons of the bed nucleus of the stria terminalis and medial amygdala in mice.Hormones and behavior · 2023Article
- Article
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Quantitative and qualitative sex difference in habenula-induced inhibition of midbrain dopamine neurons in the rat.Frontiers in behavioral neuroscience · 2023Article
- Knockdown of sexually differentiated vasopressin expression in the bed nucleus of the stria terminalis reduces social and sexual behaviour in male, but not female, mice.Journal of neuroendocrinology · 2022Article
- Neural systems that facilitate the representation of social rank.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Habenula as a Neural Substrate for Aggressive Behavior.Frontiers in psychiatry · 2022Review
- Vasopressin regulates daily rhythms and circadian clock circuits in a manner influenced by sex.Hormones and behavior · 2021Article
- Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus.Neuroendocrinology · 2021Article
- Role of Habenula in Social and Reproductive Behaviors in Fish: Comparison With Mammals.Frontiers in behavioral neuroscience · 2021Review
- DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models.Journal of pain research · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The neuropeptide arginine-vasopressin (AVP) has long been implicated in the regulation of social behavior and communication in diverse taxa, often through its actions on the V1a receptor (V1aR) and in a sex-different and steroid-dependent way. One source of sex-different brain AVP is the steroid-sensitive and sexually-dimorphic AVP neurons in the bed nucleus of the stria terminalis (BNST), a cell population that regulates social behavior in a sex-dependent manner. Potential targets of these BNST-AVP cells include the lateral habenula (LHb) and dorsal raphe (DR), areas known to be important for social behavior, yet few studies have investigated AVP action within these regions. Consequently, to test if V1aR action in the LHb or DR controls social behavior in a sexually dimorphic manner, we administered a highly-specific V1aR antagonist (or saline vehicle) in the LHb or DR of C57BL/6 male and female mice and tested its effects on social investigation, social communication (urine marking, ultrasonic vocalizations), and territorial aggression. V1aR antagonism of the LHb or DR decreased male urine marking toward unfamiliar males, but not toward unfamiliar females. Additionally, V1aR blockade of the LHb decreased ultrasonic vocalizations generated in the presence of females. Social investigation, locomotion and aggressive behavior were not altered by V1aR antagonism in either area. Blocking V1aR in the LHb or DR of females had no effect, indicating V1aR action in the DR and LHb drives sex differences in social communication.
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