Evidence map›Paper›PMID 32067595›Full record

Trial reportJournal of the American Heart Association2020

Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial.

Marilia A Correia, Paulo L Oliveira, Breno Q Farah, Lauro C Vianna, Nelson Wolosker, Pedro Puech-Leao, Daniel J Green, Gabriel G Cucato, Raphael M Ritti-Dias

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 7 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 7 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Marilia A CorreiaAssociated Graduated Program in Physical Education Universidade de Pernambuco e Universidade da Paraíba Recife Brazil.
Paulo L OliveiraGraduated Program in Rehabilitation Sciences Universidade Nove de Julho São Paulo Brazil.
Breno Q FarahFederal Rural University of Pernambuco Recife Brazil.
Lauro C ViannaFaculty of Physical Education Universidade de Brasília Brasília Brazil.
Nelson WoloskerHospital Israelita Albert Einstein São Paulo Brazil.
Pedro Puech-LeaoFaculty of Medicine University of São Paulo Brazil.
Daniel J GreenThe University of Western Australia Perth Australia.
Gabriel G CucatoHospital Israelita Albert Einstein São Paulo Brazil.
Raphael M Ritti-DiasGraduated Program in Rehabilitation Sciences Universidade Nove de Julho São Paulo Brazil.
Hospital Israelita Albert Einstein · BRUniversidade Nove de Julho · BRUniversidade de Brasília · BRUniversidade de Pernambuco · BRUniversidade de São Paulo · BRUniversidade Federal Rural de Pernambuco · BRUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Meta-analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease. Methods and Results A randomized controlled trial with peripheral artery disease patients assigned to either the IHT or control group was conducted. The IHT group performed 3 sessions per week, for 8 weeks, of unilateral handgrip exercises, consisting of 4 sets of isometric contractions for 2 minutes at 30% of maximum voluntary contraction and a 4-minute interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. The primary outcome was brachial BP. The secondary outcomes were central BP, arterial stiffness parameters, cardiac autonomic modulation, and vascular function. The IHT program reduced diastolic BP (75 [10] mm Hg preintervention versus 72 [11] mm Hg postintervention), with no change in the control group (74 [11] mm Hg preintervention versus 74 [11] mm Hg postintervention), with this between-group difference being significant (

Indexed as

Exercise TherapyHand StrengthHemodynamicsIsometric ContractionVascular StiffnessAgedBrachial ArteryBrazilFemaleHumansIntermittent ClaudicationMaleMiddle AgedPeripheral Arterial DiseaseRecovery of FunctionTime Factorsblood pressurecardiovascular systemintermittent claudicationperipheral vascular disease

Identifiers

PMID32067595
PMCPMC7070219
OpenAlexW3004703185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.