Evidence map›Paper›PMID 32067396›Full record

ArticleClinical and experimental dental research2020

A diet high in fat and fructose adversely affects osseointegration of titanium implants in rats.

Shalinie King, Carina Baptiston Tanaka, Dean Ross, Jamie J Kruzic, Itamar Levinger, Iven Klineberg, Tara C Brennan-Speranza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental dental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shalinie KingSydney Dental School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-4441-921X
Carina Baptiston TanakaSchool of Mechanical and Manufacturing Engineering, UNSW Sydney, Sydney, New South Wales, Australia.
Dean RossDepartment of Physiology and Bosch Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Jamie J KruzicSchool of Mechanical and Manufacturing Engineering, UNSW Sydney, Sydney, New South Wales, Australia.
Itamar LevingerInstitute for Health and Sport (IHES), Victoria University, Melbourne, Victoria, Australia.
Iven KlinebergSydney Dental School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Tara C Brennan-SperanzaDepartment of Physiology and Bosch Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
The University of Sydney · AUUNSW Sydney · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDiet-induced metabolic dysfunction such as type 2 diabetes mellitus increases the risk of implant failure in both dental and orthopaedic settings. We hypothesised that a diet high in fat and fructose would adversely affect peri-implant bone structure and function including osseointegration. MATERIALS AND

methodsThirty female Sprague-Dawley rats were divided into three groups (n = 10), control group (normal chow) and two intervention groups on a high-fat (60%), high-fructose (20%; HFHF) diet. Titanium implants were placed in the proximal tibial metaphysis in all groups either before commencing the diet (dHFHF group) or 6 weeks after commencing the diet (HFHF group) and observed for an 8-week healing period. Fasting blood glucose levels (fBGLs) were measured weekly. Structural and functional features of the peri-implant bone, including bone-to-implant contact (BIC), were analysed post euthanasia using microcomputed tomography, pull-out tests, and dynamic histomorphometry.

resultsThe fBGLs were unchanged across all groups. Peri-implant trabecular bone volume was reduced in the HFHF group compared with controls (p = .02). Percentage BIC was reduced in both HFHF group (25.42 ± 3.61) and dHFHF group (28.56 ± 4.07) compared with the control group (43.26 ± 3.58, p < .05) and reflected the lower pull-out loads required in those groups. Osteoblast activity was reduced in both intervention groups compared with the control group (p < .05).

conclusionThe HFHF diet compromised osseointegration regardless of whether the implant was placed before or after the onset of the diet and, despite the absence of elevated fBGLs, confirming that changes in bone cell function affected both the initiation and maintenance of osseointegration independent of blood glucose levels.

Indexed as

AnimalsBlood GlucoseBone-Implant InterfaceDental ImplantsDiet, Carbohydrate LoadingDiet, High-FatFeeding BehaviorFemaleFructoseImplants, ExperimentalModels, AnimalOsseointegrationRatsRats, Sprague-DawleyTibiaTitaniumBlood GlucoseDental ImplantsFructoseTitaniumdental implant(s)histomorphometrymicrocomputed tomographyosseointegration

Identifiers

PMID32067396
PMCPMC7025982
OpenAlexW2990747108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.