ArticleJournal of cancer research and clinical oncology2020
A transcriptional metabolic gene-set based prognostic signature is associated with clinical and mutational features in head and neck squamous cell carcinoma.
Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fasting-mimicking diets as a strategy to reprogram tumor metabolism: a systematic review.European journal of nutrition · 2026Pooled it
- An integrative analysis combining bioinformatics, network pharmacology and experimental methods identified key genes of EGCG targets in Nasopharyngeal Carcinoma.Discover oncology · 2025Article
- Generation of novel lipid metabolism-based signatures to predict prognosis and immunotherapy response for colorectal adenocarcinoma.Scientific reports · 2024Article
- Construction and validation of a folate metabolism-related gene signature for predicting prognosis in HNSCC.Journal of cancer research and clinical oncology · 2024Article
- Molecular subtype construction and prognosis model for stomach adenocarcinoma characterized by metabolism-related genes.Heliyon · 2024Article
- Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma.Discover oncology · 2024Article
- Disulfidptosis features and prognosis in head and neck squamous cell carcinoma patients: unveiling and validating the prognostic signature across cohorts.Journal of cancer research and clinical oncology · 2024Article
- Cancer metabolism and carcinogenesis.Experimental hematology & oncology · 2024Review
- Dysregulation of base excision repair factors associated with low tumor immunogenicity in head and neck cancer: implication for immunotherapy.Therapeutic advances in medical oncology · 2024Article
- Article
- Exploration of prognostic biomarkers in head and neck squamous cell carcinoma microenvironment from TCGA database.Annals of translational medicine · 2023Article
- Metabolic genes, a potential predictor of prognosis and immunogenicity of clear cell renal cell carcinoma.American journal of cancer research · 2023Article
- Identification of metabolic signatures related to metastasis and immunotherapy resistance in oral squamous cell carcinoma.American journal of translational research · 2023Article
- Molecular subtype identification and prognosis stratification by a metabolism-related gene expression signature in colorectal cancer.Journal of translational medicine · 2021Article
- Article
- A Novel Prognostic Signature Based on Metabolism-Related Genes to Predict Survival and Guide Personalized Treatment for Head and Neck Squamous Carcinoma.Frontiers in oncology · 2021Article
- Article
- Identification of a Transcriptional Prognostic Signature From Five Metabolic Pathways in Oral Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHead and neck squamous cell carcinoma (HNSCC) is a common cancer with high mortality and poor prognosis partially owing to lack of application of predictive markers. Increasing evidence has suggested that metabolic dysregulation plays an important part in tumorigenesis. We aim to identify a prognostic metabolic pathway (MP) signature in HNSCC.
methodsSingle sample gene-set enrichment analysis (ssGSEA) was used in metabolic gene sets to develop a metabolism-based prognostic risk score (MPRS) for HNSCC using Cox regression analysis (univariate, LASSO, and stepwise multiple cox analysis), which was then validated in different subgroups, and association with clinical and mutational features was analyzed.
resultsSeventy-two dysregulated metabolic pathways were identified, and a six-MP signature (6MPS) was constructed which can effectively distinguish between the high- and low-risk patients in both training and testing sets, accompanied with high sensitivity and specificity (AUC = 0.7) in prognosis prediction. 6MPS was also applicable to patients of different subgroups. Furthermore, 6MPS is not only an independent prognostic predictor but also associated with clinicopathological and mutational features. Higher tumor stage and tumor mutation burden (TMB) have a higher MPRS.
conclusion6MPS functions not only as a promising predictor of prognosis and survival but also as potential marker for therapeutic schedule monitoring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.