Evidence map›Paper›PMID 32067099›Full record

ArticleEuropean journal of nutrition2020

Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases.

Tanvi Shinde, Agampodi Promoda Perera, Ravichandra Vemuri, Shakuntla V Gondalia, David J Beale, Avinash V Karpe, Sonia Shastri, Waheedha Basheer, Benjamin Southam, Rajaraman Eri and 1 more

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In one paragraph

Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
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  6. Review
  7. Microorganisms · 2025
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  10. Nutrients · 2025
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  15. Frontiers in microbiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tanvi ShindeCentre for Food Safety and Innovation, Tasmanian Institute of Agriculture, University of Tasmania, Launceston, TAS, 7250, Australia. tanvi.shinde@utas.edu.au.ORCID http://orcid.org/0000-0002-8551-5841
Agampodi Promoda PereraSchool of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, 7250, Australia.
Ravichandra VemuriSchool of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, 7250, Australia.
Shakuntla V GondaliaCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia.
David J BealeLand and Water, Commonwealth Scientific and Industrial Research Organization (CSIRO), Ecosciences Precinct, Dutton Park, QLD, 4102, Australia.
Avinash V KarpeLand and Water, Commonwealth Scientific and Industrial Research Organization (CSIRO), Ecosciences Precinct, Dutton Park, QLD, 4102, Australia.
Sonia ShastriSchool of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, 7250, Australia.
Waheedha BasheerSchool of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, 7250, Australia.
Benjamin SouthamSchool of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, 7250, Australia.
Rajaraman EriSchool of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, 7250, Australia.
Roger StanleyCentre for Food Safety and Innovation, Tasmanian Institute of Agriculture, University of Tasmania, Launceston, TAS, 7250, Australia. roger.stanley@utas.edu.au.
University of Tasmania · AUCSIRO Land and Water · AUCSIRO Health and Biosecurity · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe research goal is to develop dietary strategies to help address the growing incidence of inflammatory bowel diseases (IBD). This study has investigated the effectiveness of green banana resistant starch (GBRS) and probiotic Bacillus coagulans MTCC5856 spores for the amelioration of dextran-sulfate sodium (DSS)-induced colitis in mice.

methodsEight-week-old C57BL/6 mice were fed standard rodent chow diet supplemented with either B. coagulans, GBRS or its synbiotic combination. After 7 days supplementation, colitis was induced by adding 2% DSS in drinking water for 7 days while continuing the supplemented diets. Animal health was monitored and after 14 days all animals were sacrificed to measure the biochemical and histochemical changes associated with each supplement type.

resultsThe disease activity index and histological damage score for DSS-control mice (6.1, 17.1, respectively) were significantly higher (p < 0.0001) than the healthy mice. Synbiotic supplementation alleviated these markers (- 67%, - 94% respectively) more adequately than B. coagulans (- 52%, - 58% respectively) or GBRS (- 57%, - 26%, respectively) alone. Compared to DSS-control synbiotic supplementation significantly (p < 0.0001) maintained expressions of tight junction proteins. Moreover, synbiotic effects accounted for ~ 40% suppression of IL-1β and ~ 29% increase in IL-10 levels in serum while also reducing C-reactive protein (- 37%) compared to that of the DSS-control. While, B. coagulans alone could not induce additional levels of short-chain fatty acid (SCFA) production beyond the caecum, the synbiotic combination with GBRS resulted in substantial increased SCFA levels across the whole length of the colon.

conclusionThe synbiotic supplementation with B. coagulans and GBRS ameliorated the overall inflammatory status of the experimental IBD model via synergistic functioning. This supports researching its application in mitigating inflammation in human IBD.

Indexed as

Bacillus coagulansColitisInflammatory Bowel DiseasesMusaProbioticsSynbioticsAnimalsColonDextran SulfateDisease Models, AnimalInflammationMiceMice, Inbred C57BLPrebioticsResistant StarchSpores, BacterialDextran SulfatePrebioticsResistant StarchBacillus sporesGreen bananaInflammatory bowel diseasesMucosal barrierPrebioticProbioticResistant starchShort-chain fatty acidsSynbiotic

Identifiers

PMID32067099
PMCPMC7669818
OpenAlexW3006388067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.