ArticleNature medicine2020
A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics.
Registry-linked trialAbstract readClinical Trial, Phase I
In one paragraph
Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02755324 (Establishing a Single-sex Controlled Human Schistosomiasis Infection Model), which is not on this map. Cited by 84 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishing a Single-sex Controlled Human Schistosomiasis Infection Model: Safety and Dose Finding
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review.PLoS pathogens · 2021Pooled it
- T cell responses in repeated controlled human schistosome infection compared to natural exposure.Nature communications · 2025Trial
- Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes.Nature communications · 2023Trial
- Heritable transgenic schistosomes as a living platform for SARS-CoV-2 neutralizing antibody secretion.Nature communications · 2026Article
- No Simple Fluke: Schistosomiasis as an Emerging Regulator of Haematopoiesis.Parasite immunology · 2026Review
- Charge-regulated hepatic γ-glutamyltranspeptidase fluorescent probe:Chemical science · 2026Article
- Advances in vaccine development through the controlled human infection models for hookworm and schistosomiasis.PLoS neglected tropical diseases · 2026Review
- Bayesian machine learning enables discovery of risk factors for hepatosplenic multimorbidity related to schistosomiasis.Nature communications · 2026Article
- Harnessing controlled human infection models to accelerate vaccine development for neglected tropical diseases: Lessons from leishmaniasis.European journal of clinical investigation · 2026Review
- Stage specific immune responses to schistosomes may explain conflicting results in malaria-schistosome coinfection studies.Infectious Disease Modelling · 2025Article
- Vaccine value profile for schistosomiasis.Vaccine · 2025Article
- Acute schistosomiasis in travellers: outcomes of a short-course therapy.Journal of travel medicine · 2025Article
- TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Comparative performance of Kato-Katz, POC-CCA and real-time PCR in detecting Schistosoma mansoni infection at different endemicity settings in northwest Ethiopia: a cross-sectional study.Tropical medicine and health · 2025Article
- Pre-clinical studies of Schistosoma mansoni vaccines: A scoping review.PLoS neglected tropical diseases · 2025Article
- How improvements to drug effectiveness impact mass drug administration for control and elimination of schistosomiasis.PLoS neglected tropical diseases · 2025Article
- Molecular detection and identification of Trichobilharzia: development of a LAMP, qPCR, and multiplex PCR toolkit.Parasites & vectors · 2025Article
- Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination.Infectious diseases of poverty · 2025Review
- Identification of a circulating carbohydrate antigen as a highly specific and sensitive target for schistosomiasis serology.Journal of clinical microbiology · 2025Article
- Antibody Responses and the Vaccine Efficacy of Recombinant Glycosyltransferase and Nicastrin AgainstPathogens (Basel, Switzerland) · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Marijke C C LangenbergDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3720-1522
Marie-Astrid Hoogerwerf *Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Jan Pieter R Koopman *Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1335-9402
Jacqueline J JanseDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Janneke Kos-van OosterhoudDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Carola FeijtDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Simon P JochemsDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-4835-1032
Claudia J de DoodDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Roos van SchuijlenburgDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Arifa Ozir-FazalalikhanDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Mikhael D ManurungDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Erliyani SartonoDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Martha T van der BeekDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Béatrice M F WinkelDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Petra H Verbeek-MenkenDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Koen A StamDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Fijs W B van LeeuwenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Pauline MeijDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.
Angela van DiepenDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Lisette van LieshoutDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Govert J van DamDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.
Paul L A M CorstjensDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Cornelis H HokkeDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-3545-7804
Maria YazdanbakhshDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-7666-1441
Leo G VisserDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Meta RoestenbergDepartment of Parasitology, Leiden University Medical Center, Leiden, the Netherlands. m.roestenberg@lumc.nl.ORCID http://orcid.org/0000-0002-5052-2830
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is insufficient to control transmission in highly endemic areas
Indexed as
Models, BiologicalAdolescentAdultAnimalsAntigens, HelminthAntiparasitic AgentsCytokinesFemaleHumansImmunity, HumoralImmunoglobulin MMaleMiddle AgedPraziquantelSchistosoma mansoniSchistosomiasis mansoniAntigens, HelminthAntiparasitic AgentsCytokinesImmunoglobulin MPraziquantelVaccines
Identifiers
PMID
32066978What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT02755324ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.