Evidence map›Paper›PMID 32066955›Full record

ArticleNature immunology2020

EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential.

Marta Derecka, Josip Stefan Herman, Pierre Cauchy, Senthilkumar Ramamoorthy, Ekaterina Lupar, Dominic Grün, Rudolf Grosschedl

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  15. Article
  16. Tmem100- and Acta2-Lineage Cells Contribute to Implant Osseointegration in a Mouse Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  17. Stem cell quiescence and its clinical relevance.World journal of stem cells · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Marta DereckaMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. derecka@ie-freiburg.mpg.de.ORCID http://orcid.org/0000-0001-6265-9781
Josip Stefan HermanMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0002-1735-0846
Pierre CauchyMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0002-0659-0799
Senthilkumar RamamoorthyMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Ekaterina LuparMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.
Dominic GrünMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID http://orcid.org/0000-0002-3364-5898
Rudolf GrosschedlMax Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. grosschedl@ie-freiburg.mpg.de.ORCID http://orcid.org/0000-0002-0058-1250
Max Planck Institute of Immunobiology and Epigenetics · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects on HSCs. Single-cell analysis of Cxcl12-abundant reticular (CAR) cells and PDGFRα

Indexed as

AnimalsCell AdhesionCell Self RenewalChromatinFemaleHematopoiesisHematopoietic Stem CellsHematopoietic Stem Cell TransplantationMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMice, KnockoutSingle-Cell AnalysisStem Cell NicheTrans-ActivatorsChromatinEbf1 protein, mouseTrans-Activators

Identifiers

PMID32066955
OpenAlexW3005619102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.