Evidence map›Paper›PMID 32066864›Full record

ArticleBone marrow transplantation2020

The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T's come into focus.

Jakob R Passweg, Helen Baldomero, Christian Chabannon, Grzegorz W Basak, Selim Corbacioglu, Rafael Duarte, Harry Dolstra, Arjan C Lankester, Mohamad Mohty, Silvia Montoto and 6 more

Abstract read
In one paragraph

Article in Bone marrow transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Haematopoietic stem cell transplantation for children and young people: is there a role for prehabilitation? A scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jakob R PasswegEBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland. jakob.passweg@usb.ch.
Helen BaldomeroEBMT Activity Survey Office, Hematology, Department of Medicine, University Hospital, Basel, Switzerland.
Christian ChabannonInstitut Paoli Calmettes & Inserm CBT-1409, Centres d'Investigations Cliniques en Biothérapies, Marseille, France.ORCID http://orcid.org/0000-0002-3755-4889
Grzegorz W BasakDepartment of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.ORCID http://orcid.org/0000-0003-3858-8180
Selim CorbaciogluPediatric Hematology, Oncology and Stem Cell Transplantation Department, Children's Hospital, Regensburg, Germany.
Rafael DuarteServicio de Hematologia y Hemoterapia, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Harry DolstraLaboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Arjan C LankesterWillem-Alexander Children's Hospital, Department of Pediatrics, Leiden University Medical Centre Leiden, Leiden, The Netherlands.
Mohamad MohtyDepartment of Hematology, Hospital Saint Antoine, Paris, France.
Silvia MontotoSt. Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Régis Peffault de LatourBMT Unit, Department of Hematology, Hospital St. Louis, Paris, France.
John A SnowdenDepartment of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Jan StyczynskiDepartment of Pediatric Hematology and Oncology, University Hospital, Collegium Medicum UMK, Bydgoszcz, Poland.
Ibrahim Yakoub-AghaCHU de Lille, LIRIC, INSERM U995, Université de Lille, 59000, Lille, France.
Nicolaus KrögerDepartment of Stem Cell Transplantation, University Hospital Eppendorf, Hamburg, Germany.
European Society for Blood and Marrow Transplantation (EBMT)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic-cell transplantation (HCT) is widely used for acquired and congenital disorders of the hematopoietic system. Number of transplants performed in Europe and associated countries continues to rise with 47,468 HCT in 42,901 patients [19,630 allogeneic (41%) and 27,838 autologous (59%)] reported by 701 centers in 50 countries in 2018. Main indications were myeloid malignancies 10,679 (25%; 97% allogeneic), lymphoid malignancies 27,318 (64%; 20% allogeneic), solid tumors 1625 (4%; 2.9% allogeneic), and nonmalignant disorders 3063 (7%; 81% allogeneic). This year's analysis focuses on cellular therapies with the marked growth in CAR T-cell therapies from 151 in 2017 to 301 patients reported in 2018. Other cellular therapy numbers show less significant changes. Important trends in HCT include a 49% increase in allogeneic HCT for chronic phase CML (although transplant numbers remain low) and a 24% increase in aplastic anemia. In autologous HCT, there is an ongoing increase in autoimmune diseases (by 19%), predominantly due to activity in multiple sclerosis. This annual report reflects current activity and highlights important trends, useful for health care planning.

Indexed as

Hematopoietic Stem Cell TransplantationReceptors, Chimeric AntigenEuropeHumansTransplantation, AutologousTransplantation, HomologousReceptors, Chimeric Antigen

Identifiers

PMID32066864
PMCPMC7391287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.