ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2020
PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability.
Erratum issuedOpen access · bronzeAbstract read
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Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Small bowel adenocarcinoma in Crohn's disease: a systematic review and meta-analysis of the prevalence, manifestation, histopathology, and outcomes.International journal of colorectal disease · 2022Pooled it
- An Open Source Automated Tumor Infiltrating Lymphocytes Algorithm for Prognosis in Primary Small Bowel Adenocarcinoma Using Routine Hematoxylin and Eosin Stained Sections.Cancer medicine · 2026Article
- GDF10 Regulates Iron-Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2.Biotechnology and applied biochemistry · 2025Article
- Medullary carcinomas of the nonampullary small intestine: association with coeliac disease, mismatch repair deficiency, PD-L1 expression, and favourable prognosis.Histopathology · 2025Article
- A small bowel adenocarcinoma harboring a DDR2 mutation in a celiac patient.Clinical journal of gastroenterology · 2024Article
- Tertiary lymphoid structures' pattern and prognostic value in primary adenocarcinoma of jejunum and ileum.World journal of surgical oncology · 2024Article
- Immune signature of small bowel adenocarcinoma and the role of tumor microenvironment.World journal of gastroenterology · 2024Article
- Alterations in p53, Microsatellite Stability and Lack of MUC5AC Expression as Molecular Features of Colorectal Carcinoma Associated with Inflammatory Bowel Disease.International journal of molecular sciences · 2023Article
- Molecular Landscape and Association With Crohn Disease of Poorly Cohesive Carcinomas of the Nonampullary Small Bowel.American journal of clinical pathology · 2023Article
- Malignant complications of celiac disease: a case series and review of the literature.Journal of medical case reports · 2022Review
- PD-L1 evaluation in the gastrointestinal tract: from biological rationale to its clinical application.Pathologica · 2022Review
- Review
- Prognostic relevance and putative histogenetic role of cytokeratin 7 and MUC5AC expression in Crohn's disease-associated small bowel carcinoma.Virchows Archiv : an international journal of pathology · 2021Article
- Association between intestinal neoplasms and celiac disease: A review.World journal of gastrointestinal oncology · 2021Review
- Review
- Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas.Annals of surgical oncology · 2021Article
- Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma.Frontiers in oncology · 2021Article
- Article
- Comment on Jun, S.Y.; et al. "Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma"Cancers · 2020Article
- Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice.Pathologica · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
70 authors at 20 institutions in 2 countries.
Paolo Giuffrida *Department of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Giovanni Arpa *Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Federica GrilloPathology Unit, Department of Surgical and Diagnostic Sciences, University of Genoa and San Martino/IST University Hospital, Genoa, Italy.
Catherine KlersyBiometry and Statistics Service, Fondazione IRCCS San Matteo Hospital, Pavia, Italy.ORCID http://orcid.org/0000-0003-0314-8548
Gianluca SampietroUnit of IBD Surgery, Luigi Sacco University Hospital, Milan, Italy.
Sandro ArdizzoneGastroenterology Unit, Luigi Sacco University Hospital, Milan, Italy.
Paolo FocianiPathology Unit, Luigi Sacco University Hospital, Milan, Italy.
Roberto FioccaPathology Unit, Department of Surgical and Diagnostic Sciences, University of Genoa and San Martino/IST University Hospital, Genoa, Italy.
Giovanni LatellaGastroenterology Unit, Department of Life and Enviromental Sciences, University of L'Aquila, L'Aquila, Italy.
Fausto SessaPathology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Antonietta D'ErricoDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), Institute of Oncology and Transplant Pathology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
Deborah MalviDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), Institute of Oncology and Transplant Pathology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
Claudia MescoliPathology Unit, Department of Medicine, University of Padua, Padua, Italy.
Massimo RuggePathology Unit, Department of Medicine, University of Padua, Padua, Italy.
Gabriella NesiDivision of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
Stefano FerreroDivision of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Daniela FurlanPathology Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.ORCID http://orcid.org/0000-0002-5958-5379
Gilberto PoggioliSurgery of the Alimentary Tract, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
Fernando RizzelloIntestinal Chronic Bowel Disease Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Maria C MacciomeiPathology Unit, San Camillo-Forlanini Hospital, Rome, Italy.
Donatella SantiniDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), Institute of Oncology and Transplant Pathology, University of Bologna, St. Orsola-Malpighi Hospital, Bologna, Italy.
Umberto VoltaDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Roberto De GiorgioDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Giacomo CaioDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Antonio CalabròDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Carolina CiacciDepartment of Medicine and Surgery, University of Salerno, Salerno, Italy.ORCID http://orcid.org/0000-0002-7426-1145
Maria D'ArmientoPublic Health Department, Federico II University of Naples, Naples, Italy.
Aroldo RizzoUnits of Pathology, Cervello Hospital, Palermo, Italy.
Gaspare SolinaUnits of General Surgery, Cervello Hospital, Palermo, Italy.
Michele MartinoDepartment of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Francesco TonelliSurgery and Translational Medicine, University of Florence, Florence, Italy.
Vincenzo VillanacciInstitute of Pathology, Spedali Civili Hospital, Brescia, Italy.
Renato CannizzaroDepartment of Gastroenterology, Centro di Riferimento Oncologico (CRO) di Aviano IRCCS, Aviano, Italy.
Vincenzo CanzonieriPathology Unit, Centro di Riferimento Oncologico (CRO) di Aviano IRCCS, Aviano, Italy.
Ada M FlorenaPathologic Anatomy Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Livia BianconeDepartment of Systems Medicine, University of Tor Vergata, Rome, Italy.
Giovanni MonteleoneDepartment of Systems Medicine, University of Tor Vergata, Rome, Italy.
Roberto CaronnaDepartment of Surgical Sciences, La Sapienza University, Rome, Italy.
Antonio CiardiDepartment of Radiological, Oncological, Pathological Sciences, Umberto I Hospital, La Sapienza University, Rome, Italy.
Luca ElliGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Flavio CaprioliGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Maurizio VecchiGastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Renata D'IncàGastroenterology Section, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Fabiana ZingoneGastroenterology Section, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Anna D'OdoricoGastroenterology Section, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Marco Vincenzo LentiDepartment of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Barbara OreggiaGeneral Surgery Unit, Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Luca Reggiani BonettiSection of Pathology, Department of Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Modena, Italy.
Marco AstegianoGeneral and Specialistic Surgery, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy.
Elena BilettaAnatomic Pathology ASL Biella, Biella, Italy.
Laura CantoroGastroenterology Unit, USL Umbria 1, Perugia, Italy.
Antonino G GiannonePathologic Anatomy Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Augusto OrlandiDepartment of Biopathology and Image Diagnostics, University of Tor Vergata, Rome, Italy.
Claudio PapiIBD Unit, San Filippo Neri Hospital, Rome, Italy.
Vittorio PerfettiInternal Medicine Unit, S.S. Annunziata Hospital, ASST-Pavia, Varzi, Italy.
Erica QuaquariniMedical Oncology Unit, IRCCS ICS Maugeri and Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Giancarlo SandriClinical Nutrition Unit, Sant'Eugenio Hospital, Rome, Italy.
Marco SilanoUnit of Human Nutrition and Health, Istituto Superiore di Sanità, Rome, Italy.
Paolo UsaiDepartment of Internal Medicine, University of Cagliari, Cagliari, Italy.
Valeria BarresiDepartment of Diagnostics and Public Health, Section of Anatomical Pathology, University and Hospital Trust of Verona, Verona, Italy.
Rachele CiccocioppoGastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. Rossi, University of Verona, Verona, Italy.
Ombretta LuinettiDepartment of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Paolo PedrazzoliDepartment of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Andrea PietrabissaDepartment of Surgery, General Surgery II, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Alessandra ViglioAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Marco PaulliAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Gino R CorazzaDepartment of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Enrico SolciaAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Alessandro VanoliAnatomic Pathology Unit, Department of Molecular Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.
Antonio Di SabatinoDepartment of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy. a.disabatino@smatteo.pv.it.ORCID http://orcid.org/0000-0002-0302-8645
University of Pavia · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Padua · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITLuigi Sacco Hospital · ITUniversity of Florence · ITUniversity of Rome Tor Vergata · ITOspedale Vincenzo Cervello · ITUniversity of Ferrara · ITUniversity of Genoa · ITUniversity of Insubria · ITUniversity of Palermo · ITUniversity of Verona · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITCarlo Forlanini Hospital · ITCentro di Riferimento Oncologico · ITFederico II University Hospital · ITFondazione Ricerca Molinette · ITIstituto Superiore di Sanità · ITOspedale degli Infermi · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small bowel adenocarcinomas (SBAs) are often associated with poor prognosis and have limited therapeutic options. Programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway blockade is an effective treatment in many microsatellite instability-high (MSI-H) solid tumors. We aimed at investigating PD-L1 and PD-1 expression in non-hereditary, non-ampullary SBAs, associated with celiac disease (CeD), Crohn's disease (CrD), or sporadic, recruited through the Small Bowel Cancer Italian Consortium. We assessed PD-L1 and PD-1 by immunohistochemistry in a series of 121 surgically resected SBAs, including 34 CeD-SBAs, 49 CrD-SBAs, and 38 sporadic SBAs. PD-L1 and PD-1 expression was correlated with several clinico-pathological features, such as the etiology, microsatellite instability status, and tumor-infiltrating lymphocyte (TIL) density. The prevalence of PD-L1 positivity according to combined positive score (CPS) was 26% in the whole cohort of SBAs, with significantly (p = 0.001) higher percentage (35%) in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs (5%). CPS ≥ 1 SBAs were significantly (p = 0.013) more frequent in MSI-H cases (41%) than in non-MSI-H ones (18%); however, 15 CPS ≥ 1 microsatellite stable SBAs were also identified. CPS ≥ 1 SBAs showed higher TIL and PD-1
Indexed as
AdenocarcinomaAdultAgedB7-H1 AntigenBiomarkers, TumorCeliac DiseaseCrohn DiseaseFemaleHumansIntestinal NeoplasmsIntestine, SmallLymphocytes, Tumor-InfiltratingMaleMicrosatellite InstabilityMiddle AgedRetrospective StudiesB7-H1 AntigenBiomarkers, TumorCD274 protein, human
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