Evidence map›Paper›PMID 32066843›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2020

Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.

Mihai Puia-Dumitrescu, Noelle Younge, Daniel K Benjamin, Katie Lawson, Cordelia Hume, Kennedy Hill, Jonathan Mengistu, Aryeona Wilson, Kanecia O Zimmerman, Kaashif Ahmad and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Observational
  7. Review
  8. Article
  9. Article
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  11. Review
  12. Article
  13. Review of Drug Utilization Studies in Neonatal Units: A Global Perspective.International journal of environmental research and public health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mihai Puia-DumitrescuDepartment of Pediatrics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7847-5204
Noelle YoungeDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Daniel K BenjaminDepartment of Economics, Clemson University, Clemson, SC, USA.
Katie LawsonDuke Clinical Research Institute, Durham, NC, USA.
Cordelia HumeDuke Clinical Research Institute, Durham, NC, USA.
Kennedy HillDuke Clinical Research Institute, Durham, NC, USA.
Jonathan MengistuDuke Clinical Research Institute, Durham, NC, USA.
Aryeona WilsonDuke Clinical Research Institute, Durham, NC, USA.
Kanecia O ZimmermanDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA.
Kaashif AhmadMEDNAX Center for Research, Education, Quality and Safety, San Antonio, TX, USA.
Rachel G GreenbergDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USA. rachel.greenberg@duke.edu.ORCID http://orcid.org/0000-0003-4156-8543

Funding

NIH Summer Research Experience Programs (R25)R25HD076475 · NICHD · DUKE UNIVERSITY · PI BENJAMIN, DANIEL K. · 2013 to 2023
$1.1M
The Microbiome and Metabolism in Postnatal Growth FailureK23DK120960 · NIDDK · DUKE UNIVERSITY · PI YOUNGE, NOELLE ELIZABETH · 2019 to 2022
$874k
Investigating polypharmacy-related adverse events in critically ill children using electronic health records and simulated drug levelsK23HD091398 · NICHD · DUKE UNIVERSITY · PI ZIMMERMAN, KANECIA OBIE · 2017 to 2020
$629k
NICHD NIH HHS HHSN275201000003CNICHD NIH HHS HHSN275201000003INICHD NIH HHS K23 HD091398NICHD NIH HHS R25 HD076475NIDDK NIH HHS K23 DK120960
6 · The paper itself

Abstract

objectiveTo evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation. STUDY

designMulticenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group.

resultsThis study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016).

conclusionsA large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.

Indexed as

HospitalsIntensive Care Units, NeonatalBirth WeightFemaleGestational AgeHumansInfantInfant, NewbornPregnancyRetrospective Studies

Identifiers

PMID32066843
PMCPMC7293630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.