ArticleJournal of perinatology : official journal of the California Perinatal Association2020
Left-sided congenital diaphragmatic hernia: can we improve survival while decreasing ECMO?
Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Correlation of Oxygen Saturation Index with Oxygenation Index in Congenital Diaphragmatic Hernia: in A Secondary Analysis of a Randomized Clinical Trial.The Journal of pediatrics · 2026Article
- Congenital diaphragmatic hernia: are improvements in ECMO & survival sustainable over time?Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Oxygenation Index and Oxygen Saturation Index in Congenital Diaphragmatic Hernia: Do Management Guidelines Make a Difference?Neonatology · 2026Article
- Utility of NT-proBNP as a biomarker in Congenital Diaphragmatic Hernia.Pediatric research · 2025Article
- Safety and Feasibility of Early Targeted Neonatal Echocardiography and a Focused Assessment Protocol in Neonates With Congenital Diaphragmatic Hernia.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Concurrent Bronchopulmonary Sequestration in Congenital Diaphragmatic Hernia: Is Frequency Increasing or Are We Better at Diagnosis?Journal of pediatrics. Clinical practice · 2025Article
- Association between initial ventilation mode and hospital outcomes for severe congenital diaphragmatic hernia.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Comparison of current to past outcomes in congenital diaphragmatic hernia using MRI observed-to-expected total fetal lung volume.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Congenital diaphragmatic hernia: quality improvement using a maximal lung protection strategy and early surgery-improved survival.European journal of pediatrics · 2024Article
- Preface: current status of diagnosis and treatment of congenital diaphragmatic hernia.World journal of pediatric surgery · 2024Article
- Longitudinal Trajectory of Ventricular Function and Pulmonary Hypertension in Congenital Diaphragmatic Hernia.The Journal of pediatrics · 2023Article
- Association Between Mortality and Ventilator Parameters in Children With Respiratory Failure on ECMO.Respiratory care · 2023Article
- Perioperative Improvement in Pulmonary Function in Infants with Congenital Diaphragmatic Hernia.The Journal of pediatrics · 2023Article
- The CDH patient perspective journey.Frontiers in pediatrics · 2023Article
- Role of palliative care in centers performing maternal-fetal interventions.Frontiers in pediatrics · 2023Article
- Congenital diaphragmatic hernia: a narrative review of controversies in neonatal management.Translational pediatrics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMortality and ECMO rates for congenital diaphragmatic hernia (CDH) remain ~30%. In 2016, we changed our CDH guidelines to minimize stimulation while relying on preductal oxygen saturation, lower mean airway pressures, stricter criteria for nitric oxide (iNO), and inotrope use. We compared rates of ECMO, survival, and survival without ECMO between the two epochs. DESIGN/
methodsRetrospective review of left-sided CDH neonates at the University of Utah/Primary Children's Hospital NICUs during pre (2003-2015, n = 163) and post (2016-2019, n = 53) epochs was conducted. Regression analysis controlled for defect size and intra-thoracic liver.
resultsFollowing guideline changes, we identified a decrease in ECMO (37 to 13%; p = 0.001) and an increase in survival without ECMO (53 to 79%, p = 0.0001). Overall survival increased from 74 to 89% (p = 0.035). CONCLUSION(S): CDH management guideline changes focusing on minimizing stimulation, using preductal saturation and less aggressive ventilator/inotrope support were associated with decreased ECMO use and improved survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.