ArticleScientific reports2020
Multi-domain cognitive assessment of male mice shows space radiation is not harmful to high-level cognition and actually improves pattern separation.
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Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Radiomodulation-The Final Frontier of Radiosurgery?Brain sciences · 2026Review
- Long-term molecular effects ofNPJ microgravity · 2026Article
- Galactic cosmic radiation produces sex-specific, circuit-selective cognitive vulnerability: countermeasure trade-offs revealed by multi-domain assessment.Research square · 2026Article
- Dose-Dependent Dual Effects of Gradient Ionizing Radiation on Neurocognition.International journal of molecular sciences · 2026Review
- A Two-Hit Model of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed by Sleep Fragmentation.Life (Basel, Switzerland) · 2025Article
- Central Nervous System Response Against Ionizing Radiation Exposure: Cellular, Biochemical, and Molecular Perspectives.Molecular neurobiology · 2025Review
- Sex-Dependent Changes in Risk-Taking Predisposition of Rats Following Space Radiation Exposure.Life (Basel, Switzerland) · 2025Article
- The longitudinal behavioral effects of acute exposure to galactic cosmic radiation in female C57BL/6J mice: Implications for deep space missions, female crews, and potential antioxidant countermeasures.Journal of neurochemistry · 2025Article
- Complex 33-beam simulated galactic cosmic radiation exposure impacts cognitive function and prefrontal cortex neurotransmitter networks in male mice.Nature communications · 2023Article
- Combined Gamma-Rays and Carbon-12 Nuclei Irradiation Modulates Brain Chemokine and Cytokine Production and Improves Spatial Learning in Tau P301S, but not 5xFAD Mouse Line.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023Article
- New Radiobiological Principles for the CNS Arising from Space Radiation Research.Life (Basel, Switzerland) · 2023Article
- Sleep and Core Body Temperature Alterations Induced by Space Radiation in Rats.Life (Basel, Switzerland) · 2023Article
- Review
- Use of an Automated Mouse Touchscreen Platform for Quantification of Cognitive Deficits After Central Nervous System Injury.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity.Frontiers in behavioral neuroscience · 2023Article
- Dynamics of Dopamine and Other Monoamines Content in Rat Brain after Single Low-Dose Carbon Nuclei Irradiation.Life (Basel, Switzerland) · 2022Article
- Adult hippocampal neurogenesis and its impairment in Alzheimer's disease.Zoological research · 2022Review
- Effects of a 33-ion sequential beam galactic cosmic ray analog on male mouse behavior and evaluation of CDDO-EA as a radiation countermeasure.Behavioural brain research · 2022Article
- Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation.Frontiers in physiology · 2022Article
- Using touchscreen-delivered cognitive assessments to address the principles of the 3Rs in behavioral sciences.Lab animal · 2021Review
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 2 countries.
Cody W Whoolery *Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sanghee Yun *Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7505-0836
Ryan P ReynoldsDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Melanie J LuceroDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ivan SolerDepartment of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Fionya H TranDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Naoki ItoDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rachel L RedfieldDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Devon R RichardsonDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hung-Ying ShihDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Phillip D RiveraDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Benjamin P C ChenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shari G BirnbaumDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-9311-0310
Ann M StoweDepartment of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA.
Amelia J EischDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. eisch@upenn.edu.ORCID http://orcid.org/0000-0001-6476-5385
The University of Texas Southwestern Medical Center · USChildren's Hospital of Philadelphia · USHope College · USKitasato University · JPSouthwestern Medical Center · USUniversity of Kentucky · USUniversity of Pennsylvania · US
Funding
Basic Science Training Program in Drug Abuse ResearchT32DA007290 · NIDA · YALE UNIVERSITY · PI SELF, DAVID W · 1992 to 2017
$6.7MRegulation of adult neurogenesis by opiatesR01DA016765 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI EISCH, AMELIA J · 2004 to 2013
$4.0MBasic Science Training Program in the Neurobiology of Mental IllnessT32MH076690 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2017
$2.3MNew Horizons in Adult NeurogenesisK02DA023555 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI EISCH, AMELIA J · 2007 to 2017
$1.1MNIDA NIH HHS K02 DA023555NIDA NIH HHS R01 DA016765NIDA NIH HHS T32 DA007290NIMH NIH HHS T32 MH076690
Abstract
Astronauts on interplanetary missions - such as to Mars - will be exposed to space radiation, a spectrum of highly-charged, fast-moving particles that includes
Indexed as
Cosmic RadiationAnimalsAstronautsBiobehavioral SciencesCognitionDentate GyrusIron IsotopesMaleMiceMice, Inbred C57BLNeuronsPaired-Associate LearningPattern Recognition, VisualReversal LearningSpace FlightWhole-Body IrradiationIron Isotopes
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.