Evidence map›Paper›PMID 32066713›Full record

ArticleTranslational psychiatry2020

Behavior and interaction imaging at 9 months of age predict autism/intellectual disability in high-risk infants with West syndrome.

Lisa Ouss, Giuseppe Palestra, Catherine Saint-Georges, Marluce Leitgel Gille, Mohamed Afshar, Hugues Pellerin, Kevin Bailly, Mohamed Chetouani, Laurence Robel, Bernard Golse and 4 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lisa OussService de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France. lisa.ouss@aphp.fr.
Giuseppe PalestraInstitut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.ORCID http://orcid.org/0000-0002-0159-2672
Catherine Saint-GeorgesInstitut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Marluce Leitgel GilleService de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Mohamed AfsharAriana Pharmaceuticals, Research Department, Paris, France.
Hugues PellerinInstitut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Kevin BaillyInstitut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Mohamed ChetouaniInstitut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France.
Laurence RobelService de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Bernard GolseService de Psychiatrie de l'Enfant, AP-HP, Hôpital Necker, 149 rue de Sèvres, 75015, Paris, France.
Rima NabboutService de Neuropédiatrie, AP-HP, Hôpital Necker, 136, Rue de Vaugirard, 75015, Paris, France.
Isabelle DesguerreService de Neuropédiatrie, AP-HP, Hôpital Necker, 136, Rue de Vaugirard, 75015, Paris, France.
Mariana Guergova-KurasAriana Pharmaceuticals, Research Department, Paris, France.
David CohenInstitut des Systèmes Intelligents et de Robotique, CNRS, UMR 7222, Sorbonne Université, 4 Place Jussieu, 75252, Paris Cedex, France. david.cohen@aphp.fr.ORCID http://orcid.org/0000-0002-3321-7375
Centre National de la Recherche Scientifique · FRHôpital Necker-Enfants Malades · FR

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-11-IDEX-0004-02Agence Nationale de la Recherche (French National Research Agency) ANR- 11-LABX-65Agence Nationale de la Recherche (French National Research Agency) ANR-12-SAMA-006-1
6 · The paper itself

Abstract

Automated behavior analysis are promising tools to overcome current assessment limitations in psychiatry. At 9 months of age, we recorded 32 infants with West syndrome (WS) and 19 typically developing (TD) controls during a standardized mother-infant interaction. We computed infant hand movements (HM), speech turn taking of both partners (vocalization, pause, silences, overlap) and motherese. Then, we assessed whether multimodal social signals and interactional synchrony at 9 months could predict outcomes (autism spectrum disorder (ASD) and intellectual disability (ID)) of infants with WS at 4 years. At follow-up, 10 infants developed ASD/ID (WS+). The best machine learning reached 76.47% accuracy classifying WS vs. TD and 81.25% accuracy classifying WS+ vs. WS-. The 10 best features to distinguish WS+ and WS- included a combination of infant vocalizations and HM features combined with synchrony vocalization features. These data indicate that behavioral and interaction imaging was able to predict ASD/ID in high-risk children with WS.

Indexed as

Autism Spectrum DisorderAutistic DisorderIntellectual DisabilitySpasms, InfantileChildHumansInfantSpeech

Identifiers

PMID32066713
PMCPMC7026100
OpenAlexW3004273599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.