ReviewTranslational psychiatry2020
Circadian rhythm disruption and mental health.
Review in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 483 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
483 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- A Systematic Review on Insomnia and Circadian Rhythms Desynchronization in Obsessive-Compulsive Disorder: From Childhood to Adulthood.Journal of sleep research · 2026Pooled it
- Pooled it
- Association Between Expressed Emotion and Relapse of Bipolar Disorder: A Systematic Review.Alpha psychiatry · 2026Pooled it
- Sleep and Circadian Interventions to Improve Athletes' Mental Health, Mood and Well-Being: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Transdiagnostic effects of combined sleep-circadian interventions on depressive symptoms and sleep outcomes in adults with mental disorders: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Associations of Social Jetlag With Depression and Anxiety in Adolescents and Young People: A Systematic Review and Meta-Analysis.Depression and anxiety · 2026Pooled it
- The Association Between Delayed Sleep-Wake Phase Disorder and Depression Among Young Individuals: A Systematic Review and Meta-Analysis: Association entre le syndrome de retard de phase et la dépression parmi les jeunes : revue systématique et méta-analyse.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Pooled it
- Ocular light exposure interventions for sleep, circadian rhythms, rest-activity cycles, mood, and cognitive function in older adults: An Overview of Cochrane and non-Cochrane Systematic Reviews.The Cochrane database of systematic reviews · 2025Pooled it
- Skin-attached bioadhesive patch enabling ultrasound deep brain stimulation and real-time electrophysiological monitoring for REM sleep enhancement.Nature communications · 2026Trial
- A digital mindfulness intervention improves sleep efficiency and heart rate variability in healthy adults.Scientific reports · 2026Trial
- DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.PloS one · 2026Trial
- Inflammatory markers and blood glucose are higher after morning vs afternoon exercise in type 2 diabetes.Diabetologia · 2025Trial
- Assessment of an App-Based Sleep Program to Improve Sleep Outcomes in a Clinical Insomnia Population: Randomized Controlled Trial.JMIR mHealth and uHealth · 2025Trial
- A circadian and app-based personalized lighting intervention for the reduction of cancer-related fatigue.Cell reports. Medicine · 2025Trial
- An examination of chronotype associations with symptoms of depression, PTSD, and sleep disturbances in US military veterans.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Establishment of a reference range for hair cortisol using a HPLC-MS/MS method in a Northern Italian population.Journal of endocrinological investigation · 2026Article
- Sleep disturbances as early indicators of incident psychiatric disease.European archives of psychiatry and clinical neuroscience · 2026Article
- Time-of-day variation in motivation for everyday behaviors: A cluster-based approach to understanding individual differences.iScience · 2026Article
- Sleep Quality and Adherence to the Mediterranean Diet in Male Young Adults: An Exploratory Study Among Amateur Soccer Players, Physically Active Individuals, and Individuals with High Sitting Time.Sports (Basel, Switzerland) · 2026Article
- Review
423 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Circadian rhythms are internal manifestations of the solar day that permit adaptations to predictable environmental temporal changes. These ~24-h rhythms are controlled by molecular clockworks within the brain that are reset daily to precisely 24 h by exposure to the light-dark cycle. Information from the master clock in the mammalian hypothalamus conveys temporal information to the entire body via humoral and neural communication. A bidirectional relationship exists between mood disorders and circadian rhythms. Mood disorders are often associated with disrupted circadian clock-controlled responses, such as sleep and cortisol secretion, whereas disruption of circadian rhythms via jet lag, night-shift work, or exposure to artificial light at night, can precipitate or exacerbate affective symptoms in susceptible individuals. Evidence suggests strong associations between circadian rhythms and mental health, but only recently have studies begun to discover the direct interactions between the circadian system and mood regulation. This review provides an overview of disrupted circadian rhythms and the relationship to behavioral health and psychiatry. The focus of this review is delineating the role of disruption of circadian rhythms on mood disorders using human night shift studies, as well as jet lag studies to identify links. We also review animal models of disrupted circadian rhythms on affective responses. Lastly, we propose low-cost behavioral and lifestyle changes to improve circadian rhythms and presumably behavioral health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.