ArticleTranslational psychiatry2020
Genomic influences on self-reported childhood maltreatment.
Registry-linked trialAbstract read
In one paragraph
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03170362 (PRIME Care), which is not on this map. Cited by 44 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 7 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PRIME Care (PRecision Medicine In MEntal Health Care)
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.Nature genetics · 2026Pooled it
- The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Translational psychiatry · 2026Pooled it
- Genetic and environment influences on childhood victimization: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nature genetics · 2024Pooled it
- Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.Biological psychiatry · 2022Pooled it
- Phenotypic and genetic analysis of a wellbeing factor score in the UK Biobank and the impact of childhood maltreatment and psychiatric illness.Translational psychiatry · 2022Pooled it
- Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach.The lancet. Psychiatry · 2021Pooled it
- Violent and sexual victimisation and incident anxiety, mood and substance use disorders in childhood and adolescence: a co-sibling study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Fine mapping of PTSD GWAS reveals a role for amygdalabioRxiv : the preprint server for biology · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- In-Depth characterization of the shared genetic architecture of suicide attempts with other major psychiatric disorders.Translational psychiatry · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Exploring the causal link between childhood maltreatment and asthma: a Mendelian randomization study.European journal of psychotraumatology · 2025Article
- Brain network controllability in genetic risk, childhood abuse, and adult anxiety.European journal of psychotraumatology · 2025Article
- Childhood trauma and subclinical cin early adulthood: A genetically informative study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.Molecular psychiatry · 2025Article
- Intergenerational association of adverse childhood experiences and perinatal mental health in adult female offspring: evidence from the longitudinal grandmothers, mothers, and their Children's health study in China.The Lancet regional health. Western Pacific · 2025Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors.
Shareefa DalvieSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. s.dalvie1@uct.ac.za.ORCID http://orcid.org/0000-0003-2333-4823
Adam X MaihoferDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4517-1623
Jonathan R I ColemanKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.ORCID http://orcid.org/0000-0002-6759-0944
Bekh BradleyAtlanta VA Health Care System, Mental Health Service Line, Decatur, GA, USA.
Gerome BreenKing's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Leslie A BrickAlpert Medical School of Brown University, Providence, RI, USA.
Chia-Yen ChenMassachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9548-5597
Karmel W ChoiBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Laramie E DuncanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1131-661X
Guia GuffantiHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Magali HaasCohen Veterans Bioscience, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6611-2449
Supriya HarnalBroad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Israel LiberzonDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.
Nicole R NugentAlpert Medical School of Brown University, Providence, RI, USA.
Allison C ProvostCohen Veterans Bioscience, Cambridge, MA, USA.
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Katy TorresDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-4201-0349
Ananda B AmstadterVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
S Bryn AustinHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Dewleen G BakerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1736-9838
Elizabeth A BolgerHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Richard A BryantDepartment of Psychology, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9607-819X
Joseph R CalabreseDepartment of Psychiatry, University Hospitals, Cleveland, OH, USA.
Douglas L DelahantyDepartment of Psychological Sciences, Kent State University, Kent, OH, USA.
Lindsay A FarrerDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Norah C FeenyDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-8590-4591
Janine D FloryDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
David ForbesDepartment of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
Sandro GaleaDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Aarti GautamUS Army Medical Research and Materiel Command, Fort Detrick, MD, USA.
Joel GelernterUS Department of Veterans Affairs, Department of Psychiatry, West Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Rasha HammamiehUS Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.
Marti JettUS Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.ORCID http://orcid.org/0000-0002-2899-0216
Angela G JunglenDepartment of Psychological Sciences, Kent State University, Kent, OH, USA.
Milissa L KaufmanHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Ronald C KesslerHarvard Medical School, Department of Health Care Policy, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4831-2305
Alaptagin KhanMcLean Hospital, Belmont, MA, USA.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lauren A M LeboisHarvard Medical School, Department of Psychiatry, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5816-9181
Charles MarmarDepartment of Psychiatry, New York University School of Medicine, New York, NY, USA.
Matig R MavissakalianDepartment of Psychiatry, University Hospitals, Cleveland, OH, USA.
Alexander McFarlaneUniversity of Adelaide, Centre for Traumatic Stress Studies, Adelaide, SA, Australia.
Meaghan O' DonnellDepartment of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.
Holly K OrcuttDepartment of Psychology, Northern Illinois University, DeKalb, IL, USA.
Robert H PietrzakU.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA.
Victoria B RisbroughDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8347-3820
Andrea L RobertsDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5023-4399
Alex O RothbaumDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Peter Roy-ByrneDepartment of Psychiatry, University of Washington, Seattle, WA, USA.
Ken RuggieroDepartment of Nursing and Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.
Antonia V SeligowskiHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Christina M SheerinVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.ORCID http://orcid.org/0000-0003-3773-641X
Derrick SiloveDepartment of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Jordan W SmollerMassachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0381-6334
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9564-2871
Martin H TeicherHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Robert J UrsanoDepartment of Psychiatry, Uniformed Services University, Bethesda, MD, USA.
Miranda Van HooffUniversity of Adelaide, Centre for Traumatic Stress Studies, Adelaide, SA, Australia.
Sherry WinternitzHarvard Medical School, Department of Psychiatry, Boston, MA, USA.
Jonathan D WolffMcLean Hospital, Belmont, MA, USA.
Rachel YehudaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hongyu ZhaoDepartment of Biostatistics, Yale University, New Haven, CT, USA.
Lori A ZoellnerDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Karestan C KoenenMassachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5766-8923
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MModifiable Risk and Protective Factors for Suicidal Behaviors in the US ArmyU01MH087981 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI STEIN, MURRAY B., URSANO, ROBERT J. · 2009 to 2013
$65.0MTraining Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9MPsychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7MUnderstanding the transgenerational epigenetic effect of maternal psychosocial trauma exposure on infants via lncRNA-sequencingR01HD102974 · NICHD · MCLEAN HOSPITAL · PI KLENGEL, TORSTEN, KOEN , NASTASSJA · 2020 to 2024
$2.9M4/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124847 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M, SEBAT, JONATHAN · 2021 to 2025
$2.1MNeurobiology of Traumatic Dissociation in a Transdiagnostic Study of Women with Childhood MaltreatmentR21MH112956 · NIMH · MCLEAN HOSPITAL · PI KAUFMAN, MILISSA L · 2017 to 2018
$446kRisk and Protective Factors for Adjustment of College Women After a Mass ShootingR21MH085436 · NIMH · NORTHERN ILLINOIS UNIVERSITY · PI ORCUTT, HOLLY K · 2008 to 2009
$352kNeurobiology of Self-Referential Processing in Posttraumatic Stress Disorder Dysfunction and RecoveryF32MH109274 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2016 to 2018
$174kNCATS NIH HHS UL1 TR001863NICHD NIH HHS R01 HD102974NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH124847NIMH NIH HHS R21 MH085436NIMH NIH HHS T32 MH017119NIMH NIH HHS U01 MH087981NIMH NIH HHS U01 MH109539
Abstract
Childhood maltreatment is highly prevalent and serves as a risk factor for mental and physical disorders. Self-reported childhood maltreatment appears heritable, but the specific genetic influences on this phenotype are largely unknown. The aims of this study were to (1) identify genetic variation associated with self-reported childhood maltreatment, (2) estimate SNP-based heritability (h
Indexed as
Child AbuseStress Disorders, Post-TraumaticChildForkhead Transcription FactorsGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansRepressor ProteinsSelf ReportForkhead Transcription FactorsFOXP1 protein, humanRepressor Proteins
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Read underepoch 390
Registered trials
NCT03170362ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.