ArticleTranslational psychiatry2020
Epigenetic signatures of attachment insecurity and childhood adversity provide evidence for role transition in the pathogenesis of perinatal depression.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Association between Childhood Exposure to Family Violence and Telomere Length: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- The relationship between maternal attachment, maternal self-efficacy, and postpartum depressive symptoms in mothers during the early postpartum period: a cross-sectional study.BMC pregnancy and childbirth · 2026Article
- Experiences in close relationships, interpersonal trust and OXTR expression in individuals with childhood maltreatment.Borderline personality disorder and emotion dysregulation · 2026Article
- The neurobiological effects of childhood maltreatment on brain structure, function, and attachment.European archives of psychiatry and clinical neuroscience · 2025Review
- Biomarkers of reproductive psychiatric disorders.The British journal of psychiatry : the journal of mental science · 2025Review
- The impact of the early environment on oxytocin receptor epigenetics and potential therapeutic implications.Pediatric research · 2025Review
- A narrative on the neurobiological roots of attachment-system functioning.Communications psychology · 2024Review
- A perspective-based analysis of attachment from prenatal period to second year postnatal life.Frontiers in psychology · 2024Review
- Deciphering and Targeting the ESR2-miR-10a-5p-BDNF Axis in the Prefrontal Cortex: Advancing Postpartum Depression Understanding and Therapeutics.Research (Washington, D.C.) · 2024Article
- Maternal outcomes related to Genetic and epigenetic Variation in the oxytocin system: A scoping review.Comprehensive psychoneuroendocrinology · 2023Article
- The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity.Translational psychiatry · 2023Article
- Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions.Molecular neurobiology · 2023Review
- Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.Biological research for nursing · 2023Article
- Coping as a Mediator between Attachment and Depressive Symptomatology Either in Pregnancy or in the Early Postpartum Period: A Structural Equation Modelling Approach.Brain sciences · 2023Article
- The Mother-Baby Bond: Role of Past and Current Relationships.Children (Basel, Switzerland) · 2023Article
- Psychological and biological mechanisms linking trauma with cardiovascular disease risk.Translational psychiatry · 2023Review
- Evaluating the challenges and reproducibility of studies investigating DNA methylation signatures of psychological stress.Epigenomics · 2022Review
- Individual Differences in Relative Telomere Length in Mentally Healthy Subjects: The Effect ofRussian journal of genetics · 2022Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
Early life adversity and insecure attachment style are known risk factors for perinatal depression. The biological pathways linking these experiences, however, have not yet been elucidated. We hypothesized that overlap in patterns of DNA methylation in association with each of these phenomena could identify genes and pathways of importance. Specifically, we wished to distinguish between allostatic-load and role-transition hypotheses of perinatal depression. We conducted a large-scale analysis of methylation patterns across 5 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.