ArticleTranslational psychiatry2020
Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Genetically Predicted Vegetable Intake and Cardiovascular Diseases and Risk Factors: An Investigation with Mendelian Randomization.Nutrients · 2023Pooled it
- Comparing genome-wide significant and chemosensory variants as instruments for dietary patterns in Mendelian randomization.International journal of epidemiology · 2026Article
- Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.EBioMedicine · 2026Article
- A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics.BMC medicine · 2026Article
- Dietary patterns and emotion dysregulation in borderline personality disorder and eating disorders as a shared mechanism underlying symptom severity.Scientific reports · 2026Article
- The associations between diet-induced inflammation and health outcomes: a population-based phenome-wide association study.NPJ science of food · 2025Article
- The contribution of gametic phase disequilibrium to the heritability of complex traits.Nature genetics · 2025Article
- Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.Reproductive biology and endocrinology : RB&E · 2025Article
- Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy.Genome research · 2024Article
- Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers.PLoS genetics · 2024Article
- A Genome-Wide Interaction Study of Erythrocyte ω-3 Polyunsaturated Fatty Acid Species and Memory in the Framingham Heart Study Offspring Cohort.The Journal of nutrition · 2024Article
- Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci.Schizophrenia bulletin · 2023Article
- New Insights into Polygenic Score-Lifestyle Interactions for Cardiometabolic Risk Factors from Genome-Wide Interaction Analyses.Nutrients · 2023Article
- Prediction of Suicidal Behaviors in the Middle-aged Population: Machine Learning Analyses of UK Biobank.JMIR public health and surveillance · 2023Article
- Editorial: Causal inference in diet, nutrition and health outcomes.Frontiers in nutrition · 2023Article
- Socioeconomic status may affect association of vegetable intake with risk of ischemic cardio-cerebral vascular disease: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Article
- Exploring Lead loci shared between schizophrenia and Cardiometabolic traits.BMC genomics · 2022Article
- Beef intake and risk of rheumatoid arthritis: Insights from a cross-sectional study and two-sample Mendelian randomization.Frontiers in nutrition · 2022Article
- A genome-wide association study of a rage-related misophonia symptom and the genetic link with audiological traits, psychiatric disorders, and personality.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 5 countries.
Funding
Abstract
Motivated by observational studies that report associations between schizophrenia and traits, such as poor diet, increased body mass index and metabolic disease, we investigated the genetic contribution to dietary intake in a sample of 335,576 individuals from the UK Biobank study. A principal component analysis applied to diet question item responses generated two components: Diet Component 1 (DC1) represented a meat-related diet and Diet Component 2 (DC2) a fish and plant-related diet. Genome-wide association analysis identified 29 independent single-nucleotide polymorphisms (SNPs) associated with DC1 and 63 SNPs with DC2. Estimated from over 35,000 3rd-degree relative pairs that are unlikely to share close family environments, heritabilities for both DC1 and DC2 were 0.16 (standard error (s.e.) = 0.05). SNP-based heritability was 0.06 (s.e. = 0.003) for DC1 and 0.08 (s.e = 0.004) for DC2. We estimated significant genetic correlations between both DCs and schizophrenia, and several other traits. Mendelian randomisation analyses indicated a negative uni-directional relationship between liability to schizophrenia and tendency towards selecting a meat-based diet (which could be direct or via unidentified correlated variables), but a bi-directional relationship between liability to schizophrenia and tendency towards selecting a fish and plant-based diet consistent with genetic pleiotropy.
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Registered trials
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