ArticleTranslational psychiatry2020
Effects of a patient-derived de novo coding alteration of CACNA1I in mice connect a schizophrenia risk gene with sleep spindle deficits.
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Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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31citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort.Brain : a journal of neurology · 2022Pooled it
- Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice.Science advances · 2026Article
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
- Common Genomic and Proteomic Alterations Related to Disturbed Neural Oscillatory Activity in Schizophrenia.International journal of molecular sciences · 2025Review
- Two pairs of CACNA1I (CaV3.3) variants with opposite effects on channel function cause neurodevelopmental disorders of varying severity.PLoS genetics · 2025Article
- Muscarinic Receptor Activation Preferentially Inhibits Rebound in Vulnerable Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct structural and functional connectivity of genetically segregated thalamoreticular subnetworks.Cell reports · 2024Article
- Muscarinic receptor activation preferentially inhibits rebound in vulnerable dopaminergic neurons.bioRxiv : the preprint server for biology · 2024Article
- Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice.Cell reports. Medicine · 2024Article
- Altered Sleep Oscillations as Neurophysiological Biomarkers of Schizophrenia.Advances in neurobiology · 2024Review
- Sleep-Deep-Learner is taught sleep-wake scoring by the end-user to complete each record in their style.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Sleep-Deep-Net learns sleep wake scoring from the end-user and completes each record in their style.bioRxiv : the preprint server for biology · 2023Article
- Adolescent sleep defects and dopaminergic hyperactivity in mice with a schizophrenia-linked Shank3 mutation.Sleep · 2023Article
- IntelliSleepScorer, a software package with a graphic user interface for automated sleep stage scoring in mice based on a light gradient boosting machine algorithm.Scientific reports · 2023Article
- An examination of plasma autoantibodies against voltage gated calcium channels in schizophrenia.Brain, behavior, & immunity - health · 2023Article
- Sleep spindles in people with schizophrenia, schizoaffective disorders or bipolar disorders: a pilot study in a general population-based cohort.BMC psychiatry · 2022Article
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants.European archives of psychiatry and clinical neuroscience · 2022Article
- Circuits and components of delta wave regulation.Brain research bulletin · 2022Review
Corrections and comments
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Authors and funding
22 authors at 4 institutions in 2 countries.
Ayan GhoshalStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
David S UygunDepartment of Psychiatry, VA Boston Healthcare System & Harvard Medical School, Boston, MA, USA.
Lingling YangStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
James M McNallyDepartment of Psychiatry, VA Boston Healthcare System & Harvard Medical School, Boston, MA, USA.
Violeta G Lopez-HuertaStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Mario A Arias-GarciaStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
David Baez-NietoStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Andrew AllenStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Megan FitzgeraldStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Soonwook ChoiStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Qiangge ZhangMcGovern Institute for Brain Research, MIT, Cambridge, MA, USA.
Jen M HopeStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Karena YanStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Xiaohong MaoNovartis Institutes for BioMedical Research, 181 Mass Ave., Cambridge, MA, 02139, USA.
Thomas B NicholsonNovartis Institutes for BioMedical Research, 181 Mass Ave., Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-7555-9456
Kazuo ImaizumiWyss Institute, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7165-9978
Zhanyan FuStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Guoping FengStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8021-277X
Ritchie E BrownDepartment of Psychiatry, VA Boston Healthcare System & Harvard Medical School, Boston, MA, USA.
Robert E StreckerDepartment of Psychiatry, VA Boston Healthcare System & Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9453-3670
Shaun M PurcellBrigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jen Q PanStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. jpan@broadinstitute.org.
Broad Institute · USHarvard University · USBrigham and Women's Hospital · USMcGovern Institute for Brain Research · US
Funding
Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1MTRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5MProject 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1MTHE SYNAPTIC BASIS OF SLEEP CYCLE CONTROLR01MH039683 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BROWN, RITCHIE EDWARD · 1985 to 2017
$3.8MDissecting the role of thalamic inhibition in neurodevelopmental diseasesR01NS098505 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING, HALASSA, MICHAEL M · 2016 to 2020
$3.2MTHE SYNAPTIC BASIS OF SLEEP CYCLE CONTROLR37MH039683 · NIMH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MCCARLEY, ROBERT W · 1987 to 2006
$3.1MHigh-Throughput Screens for CaV3.3 Selective T-type Calcium Channel ModulatorsR01MH115045 · NIMH · BROAD INSTITUTE, INC. · PI COTTRELL, JEFFREY RICHARD, PAN, JEN QIAN · 2018 to 2020
$2.3MSoftware for the analysis of large-scale genotyping and sequencing studiesR01HG005827 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI PURCELL, SHAUN M · 2010 to 2016
$2.1MShank3 in Synaptic Function and AutismR01MH097104 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING · 2012 to 2016
$2.0MPotentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleR01MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2022 to 2023
$1.8MFunctional annotation of a comprehensive set of SCN2A variantsR21NS110355 · NINDS · BROAD INSTITUTE, INC. · PI GEORGE, ALFRED L., PAN, JEN QIAN · 2018 to 2019
$443kUsing CRISPR-Cas9 genetic abscission in vivo to study the role of GABA-A receptors of the thalamic reticular nucleus in regulating non-rapid-eye-movement sleep and drug induced sleepIK2BX004905 · VA · VA BOSTON HEALTH CARE SYSTEM · PI UYGUN, DAVID SAMUEL · 2020 to 2024
–BLRD VA I01 BX001356BLRD VA I01 BX002774BLRD VA I01 BX004500BLRD VA IK2 BX002130BLRD VA IK2 BX004905BLRD VA IK6 BX005714NHGRI NIH HHS R01 HG005827NHLBI NIH HHS P01 HL095491NHLBI NIH HHS T32 HL007901NIMH NIH HHS R01 MH039683NIMH NIH HHS R01 MH097104NIMH NIH HHS R01 MH115045NIMH NIH HHS R01 MH131719NINDS NIH HHS R01 NS098505NINDS NIH HHS R21 NS110355NINDS NIH HHS U54 NS108874U.S. Department of Health & Human Services | National Institutes of Health (NIH) BX001356U.S. Department of Health & Human Services | National Institutes of Health (NIH) BX002130U.S. Department of Health & Human Services | National Institutes of Health (NIH) BX002774U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL007901U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL095491U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) HG005827U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH039683U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH097104U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH115045U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS098505U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS110355
Abstract
CACNA1I, a schizophrenia risk gene, encodes a subtype of voltage-gated T-type calcium channel Ca
Indexed as
Calcium Channels, T-TypeSchizophreniaAnimalsElectroencephalographyHumansMiceSleepSleep, REMCACNA1I protein, humanCalcium Channels, T-Type
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